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• W1994417280 abstract "Post-translational modifications of DNA (changes in the chemical structure of individual bases that occur without changes in the DNA sequence) are known to alter gene expression. They are believed to result in frequently deleterious phenotypic changes, such as cancer. Methylation of adenine, methylation and hydroxymethylation of cytosine, and guanine oxidation are the primary DNA base modifications identified to date. Here we show it is possible to use surface-enhanced Raman spectroscopy (SERS) to detect these primary DNA base modifications. SERS detection of modified DNA bases is label-free and requires minimal additional sample preparation, reducing the possibility of additional chemical modifications induced prior to measurement. This approach shows the feasibility of DNA base modification assessment as a potentially routine analysis that may be further developed for clinical diagnostics." @default.
• W1994417280 created "2016-06-24" @default.
• W1994417280 creator A5069086177 @default.
• W1994417280 creator A5085530889 @default.
• W1994417280 date "2011-12-01" @default.
• W1994417280 modified "2023-10-16" @default.
• W1994417280 title "Detecting Chemically Modified DNA Bases Using Surface-Enhanced Raman Spectroscopy" @default.
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• W1994417280 doi "https://doi.org/10.1021/jz201423b" @default.
• W1994417280 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3888867" @default.
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• W1994417280 hasPublicationYear "2011" @default.
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