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• W1994418273 abstract "Proinflammatory cytokines, such as tumour necrosis factor<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>α</mml:mi></mml:math>(TNF<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>α</mml:mi></mml:math>), play fundamental roles in the pathogenesis of acute pancreatitis (AP). The aim of this study was to determine if polymorphisms in the TNF<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>α</mml:mi></mml:math>gene are associated with AP. Two polymorphisms located in the promoter region (positions<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mo>−</mml:mo><mml:mn>308</mml:mn></mml:math>and<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mo>−</mml:mo><mml:mn>238</mml:mn></mml:math>) in TNF<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>α</mml:mi></mml:math>gene were determined using polymerase chain reaction- (PCR-) restriction fragment length polymorphism (RFLP) methods in 103 patients with AP and 92 healthy controls. Odds ratios (ORs) and 95% confidence intervals (CI) were estimated using logistic regression analysis adjusted for age, sex, BMI and smoking. The frequencies of TNF<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>α</mml:mi></mml:math>polymorphisms were both similar in patients with mild or severe pancreatitis, so were in pancreatitis patients and in controls. We suggest that both SNPs of TNF<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>α</mml:mi></mml:math>are not genetic risk factor for AP susceptibility (OR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mo>=</mml:mo></mml:math>1.63; 95% CI: 1.13−4.01 for TNF<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:msup><mml:mi>α</mml:mi><mml:mrow><mml:mo>−</mml:mo><mml:mn>308</mml:mn></mml:mrow></mml:msup></mml:math>and OR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mo>=</mml:mo></mml:math>0.86; 95% CI: 0.75−1.77 for TNF<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:msup><mml:mi>α</mml:mi><mml:mrow><mml:mo>−</mml:mo><mml:mn>238</mml:mn></mml:mrow></mml:msup></mml:math>)." @default.
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• W1994418273 date "2010-01-01" @default.
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• W1994418273 title "Polymorphisms in Tumour Necrosis Factor Alpha (TNF<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>α</mml:mi></mml:math>) Gene in Patients with Acute Pancreatitis" @default.
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