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• W1994420360 endingPage "e1003200" @default.
• W1994420360 startingPage "e1003200" @default.
• W1994420360 abstract "The X chromosome is present as a single copy in the heterogametic sex, and this hemizygosity is expected to drive unusual patterns of evolution on the X relative to the autosomes. For example, the hemizgosity of the X may lead to a lower chromosomal effective population size compared to the autosomes suggesting that the X might be more strongly affected by genetic drift. However, the X may also experience stronger positive selection than the autosomes because recessive beneficial mutations will be more visible to selection on the X where they will spend less time being masked by the dominant, less beneficial allele - a proposal known as the faster-X hypothesis. Thus, empirical studies demonstrating increased genetic divergence on the X chromosome could be indicative of either adaptive or non-adaptive evolution. We measured gene expression in Drosophila species and in D. melanogaster inbred strains for both embryos and adults. In the embryos we found that expression divergence is on average more than 20% higher for genes on the X chromosome relative to the autosomes, but in contrast, in the inbred strains gene expression variation is significantly lower on the X chromosome. Furthermore, expression divergence of genes on Muller's D element is significantly greater along the branch leading to the obscura sub-group, in which this element segregates as a neo-X chromosome. In the adults, divergence is greatest on the X chromosome for males, but not for females, yet in both sexes inbred strains harbour the lowest level of gene expression variation on the X chromosome. We consider different explanations for our results and conclude that they are most consistent within the framework of the faster-X hypothesis." @default.
• W1994420360 created "2016-06-24" @default.
• W1994420360 creator A5042671050 @default.
• W1994420360 creator A5045373288 @default.
• W1994420360 creator A5062001106 @default.
• W1994420360 creator A5066735581 @default.
• W1994420360 date "2012-12-27" @default.
• W1994420360 modified "2023-10-18" @default.
• W1994420360 title "An Excess of Gene Expression Divergence on the X Chromosome in Drosophila Embryos: Implications for the Faster-X Hypothesis" @default.
• W1994420360 cites W1590291211 @default.
• W1994420360 cites W1689369637 @default.
• W1994420360 cites W1955170827 @default.
• W1994420360 cites W1968376884 @default.
• W1994420360 cites W1974423219 @default.
• W1994420360 cites W1980678014 @default.
• W1994420360 cites W1980789664 @default.
• W1994420360 cites W1982510939 @default.
• W1994420360 cites W1983275320 @default.
• W1994420360 cites W1986183145 @default.
• W1994420360 cites W1991312188 @default.
• W1994420360 cites W1997237756 @default.
• W1994420360 cites W1998856570 @default.
• W1994420360 cites W2002794144 @default.
• W1994420360 cites W2004798712 @default.
• W1994420360 cites W2006413392 @default.
• W1994420360 cites W2012354488 @default.
• W1994420360 cites W2012457691 @default.
• W1994420360 cites W2012891736 @default.
• W1994420360 cites W2015612505 @default.
• W1994420360 cites W2022651039 @default.
• W1994420360 cites W2023573993 @default.
• W1994420360 cites W2026976170 @default.
• W1994420360 cites W2037594820 @default.
• W1994420360 cites W2043835674 @default.
• W1994420360 cites W2046233233 @default.
• W1994420360 cites W2047647995 @default.
• W1994420360 cites W2048320981 @default.
• W1994420360 cites W2051147560 @default.
• W1994420360 cites W2054837796 @default.
• W1994420360 cites W2059484277 @default.
• W1994420360 cites W2063841934 @default.
• W1994420360 cites W2068974811 @default.
• W1994420360 cites W2069421662 @default.
• W1994420360 cites W2072201802 @default.
• W1994420360 cites W2072718843 @default.
• W1994420360 cites W2073583691 @default.
• W1994420360 cites W2075848394 @default.
• W1994420360 cites W2084152659 @default.
• W1994420360 cites W2085454778 @default.
• W1994420360 cites W2086391970 @default.
• W1994420360 cites W2093017030 @default.
• W1994420360 cites W2094902224 @default.
• W1994420360 cites W2096838350 @default.
• W1994420360 cites W2098274585 @default.
• W1994420360 cites W2103845670 @default.
• W1994420360 cites W2105557836 @default.
• W1994420360 cites W2106188986 @default.
• W1994420360 cites W2109601111 @default.
• W1994420360 cites W2113244577 @default.
• W1994420360 cites W2113289439 @default.
• W1994420360 cites W2114945486 @default.
• W1994420360 cites W2116015974 @default.
• W1994420360 cites W2116843300 @default.
• W1994420360 cites W2117925179 @default.
• W1994420360 cites W2120024428 @default.
• W1994420360 cites W2121547736 @default.
• W1994420360 cites W2121950969 @default.
• W1994420360 cites W2122152054 @default.
• W1994420360 cites W2122632046 @default.
• W1994420360 cites W2131160279 @default.
• W1994420360 cites W2131413085 @default.
• W1994420360 cites W2135096935 @default.
• W1994420360 cites W2135364337 @default.
• W1994420360 cites W2136209500 @default.
• W1994420360 cites W2137648598 @default.
• W1994420360 cites W2138967315 @default.
• W1994420360 cites W2139522703 @default.
• W1994420360 cites W2140249674 @default.
• W1994420360 cites W2140603917 @default.
• W1994420360 cites W2142668377 @default.
• W1994420360 cites W2144907278 @default.
• W1994420360 cites W2148369736 @default.
• W1994420360 cites W2152633723 @default.
• W1994420360 cites W2154514055 @default.
• W1994420360 cites W2155593623 @default.
• W1994420360 cites W2158560625 @default.
• W1994420360 cites W2160748470 @default.
• W1994420360 cites W2162662933 @default.
• W1994420360 cites W2163713616 @default.
• W1994420360 cites W2169691228 @default.
• W1994420360 cites W2170355493 @default.
• W1994420360 cites W3028418616 @default.
• W1994420360 cites W4240779520 @default.
• W1994420360 cites W4242013406 @default.
• W1994420360 cites W4249939244 @default.
• W1994420360 doi "https://doi.org/10.1371/journal.pgen.1003200" @default.
• W1994420360 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3531489" @default.
• W1994420360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23300473" @default.

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