FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994421806> ?p ?o ?g. }

• W1994421806 abstract "Because fulminant hepatic failure has a poor prognosis without liver transplantation, it is required to develop new therapies directed toward hepatocyte protection and regeneration. Previously, we showed the anti-apoptotic effects of a prostaglandin E2 EP4-receptor agonist (PGE2R-A) in a rat model of acute liver failure. The aim of this study is to determine the anti-apoptotic mechanism underlying the hepatocyte protective effect of PGE2R-A in vitro. Method: (1) Apoptosis was induced in HepG2 cells using CH11, an agonistic anti-Fas antibody. The apoptosis index (percentage of apoptotic cells with respect to the total number of cells) was sequentially estimated after the administration of CH11 alone or CH11 together with indomethacin or PGE2R-A (ONO-AE1-437). (2) The expression levels of Bcl-xL and Mcl-1, members of the anti-apoptotic Bcl-2 family, were sequentially determined by western blot analysis after treatment with PGE2R-A. Results: (1) Apoptosis indexes 6h after treatment with CH11 alone, CH11 plus indomethacin, and CH11 plus PGE2R-A were 24, 42, and 16%, respectively. (2) The expression level of the Bcl-xL protein and mRNA significantly increased 30-180min after treatment with PGE2R-A, while indomethacin decreased the expression levels of Mcl-1 proteins. Conclusion: Direct induction of Bcl-xL plays an important role in the hepatocyte protective effects induced by PGE2R-A." @default.
• W1994421806 created "2016-06-24" @default.
• W1994421806 creator A5002059217 @default.
• W1994421806 creator A5013122723 @default.
• W1994421806 creator A5025762592 @default.
• W1994421806 creator A5029479458 @default.
• W1994421806 creator A5072660752 @default.
• W1994421806 date "2004-07-01" @default.
• W1994421806 modified "2023-09-25" @default.
• W1994421806 title "Induction of Bcl-xL is a possible mechanism of anti-apoptotic effect by prostaglandin E2 EP4-receptor agonist in human hepatocellular carcinoma HepG2 cells" @default.
• W1994421806 cites W1685016018 @default.
• W1994421806 cites W1983231842 @default.
• W1994421806 cites W1993899393 @default.
• W1994421806 cites W1994888307 @default.
• W1994421806 cites W1995740586 @default.
• W1994421806 cites W1998516079 @default.
• W1994421806 cites W1999690246 @default.
• W1994421806 cites W2003375553 @default.
• W1994421806 cites W2008047936 @default.
• W1994421806 cites W2013690042 @default.
• W1994421806 cites W2030033188 @default.
• W1994421806 cites W2063176993 @default.
• W1994421806 cites W2067891203 @default.
• W1994421806 cites W2071328955 @default.
• W1994421806 cites W2083071121 @default.
• W1994421806 cites W2087942074 @default.
• W1994421806 cites W2093049965 @default.
• W1994421806 cites W2134454137 @default.
• W1994421806 cites W2138053123 @default.
• W1994421806 cites W2143531222 @default.
• W1994421806 cites W2145152689 @default.
• W1994421806 cites W2154084738 @default.
• W1994421806 cites W2160047050 @default.
• W1994421806 cites W2163688402 @default.
• W1994421806 cites W2323670250 @default.
• W1994421806 cites W2324393023 @default.
• W1994421806 cites W2418313134 @default.
• W1994421806 cites W2430919517 @default.
• W1994421806 cites W2465530914 @default.
• W1994421806 cites W246735762 @default.
• W1994421806 cites W25906118 @default.
• W1994421806 cites W1984706445 @default.
• W1994421806 doi "https://doi.org/10.1016/j.hepres.2004.03.001" @default.
• W1994421806 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15203082" @default.
• W1994421806 hasPublicationYear "2004" @default.
• W1994421806 type Work @default.
• W1994421806 sameAs 1994421806 @default.
• W1994421806 citedByCount "6" @default.
• W1994421806 countsByYear W19944218062012 @default.
• W1994421806 countsByYear W19944218062014 @default.
• W1994421806 countsByYear W19944218062022 @default.
• W1994421806 crossrefType "journal-article" @default.
• W1994421806 hasAuthorship W1994421806A5002059217 @default.
• W1994421806 hasAuthorship W1994421806A5013122723 @default.
• W1994421806 hasAuthorship W1994421806A5025762592 @default.
• W1994421806 hasAuthorship W1994421806A5029479458 @default.
• W1994421806 hasAuthorship W1994421806A5072660752 @default.
• W1994421806 hasConcept C104317684 @default.
• W1994421806 hasConcept C126322002 @default.
• W1994421806 hasConcept C134018914 @default.
• W1994421806 hasConcept C170493617 @default.
• W1994421806 hasConcept C190283241 @default.
• W1994421806 hasConcept C202751555 @default.
• W1994421806 hasConcept C2776200302 @default.
• W1994421806 hasConcept C2776415932 @default.
• W1994421806 hasConcept C2777956040 @default.
• W1994421806 hasConcept C2778019345 @default.
• W1994421806 hasConcept C2778938600 @default.
• W1994421806 hasConcept C2779609443 @default.
• W1994421806 hasConcept C2911091166 @default.
• W1994421806 hasConcept C2911118192 @default.
• W1994421806 hasConcept C502942594 @default.
• W1994421806 hasConcept C55493867 @default.
• W1994421806 hasConcept C71924100 @default.
• W1994421806 hasConcept C86803240 @default.
• W1994421806 hasConcept C98274493 @default.
• W1994421806 hasConceptScore W1994421806C104317684 @default.
• W1994421806 hasConceptScore W1994421806C126322002 @default.
• W1994421806 hasConceptScore W1994421806C134018914 @default.
• W1994421806 hasConceptScore W1994421806C170493617 @default.
• W1994421806 hasConceptScore W1994421806C190283241 @default.
• W1994421806 hasConceptScore W1994421806C202751555 @default.
• W1994421806 hasConceptScore W1994421806C2776200302 @default.
• W1994421806 hasConceptScore W1994421806C2776415932 @default.
• W1994421806 hasConceptScore W1994421806C2777956040 @default.
• W1994421806 hasConceptScore W1994421806C2778019345 @default.
• W1994421806 hasConceptScore W1994421806C2778938600 @default.
• W1994421806 hasConceptScore W1994421806C2779609443 @default.
• W1994421806 hasConceptScore W1994421806C2911091166 @default.
• W1994421806 hasConceptScore W1994421806C2911118192 @default.
• W1994421806 hasConceptScore W1994421806C502942594 @default.
• W1994421806 hasConceptScore W1994421806C55493867 @default.
• W1994421806 hasConceptScore W1994421806C71924100 @default.
• W1994421806 hasConceptScore W1994421806C86803240 @default.
• W1994421806 hasConceptScore W1994421806C98274493 @default.
• W1994421806 hasLocation W19944218061 @default.
• W1994421806 hasLocation W19944218062 @default.
• W1994421806 hasOpenAccess W1994421806 @default.
• W1994421806 hasPrimaryLocation W19944218061 @default.
• W1994421806 hasRelatedWork W1970287328 @default.

• next