Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994422927> ?p ?o ?g. }
- W1994422927 endingPage "1098" @default.
- W1994422927 startingPage "1089" @default.
- W1994422927 abstract "Transforming growth factor-β (TGF-β) regulates epithelial tissue homeostasis by activating processes that control cell cycle arrest, differentiation and apoptosis. Disruption of the TGF-β signaling pathway often occurs in colorectal cancers. Earlier, we have shown that TGF-β induces apoptosis through the transcription factor Smad3. Affymetrix oligonucleotide microarrays were used to identify TGF-β/Smad3 target genes that regulate apoptosis in rat intestinal epithelial cells (RIE-1). We found that TGF-β repressed the expression of the inhibitor of differentiation (Id) gene family. Knockdown of Id1 and Id2 gene expression induced apoptosis in RIE-1 cells, whereas overexpression of Id2 attenuated TGF-β-induced apoptosis. TranSignal Protein/DNA arrays were used to identify the hypoxia-inducing factor-1 (HIF-1) as a downstream target of TGF-β. HIF-1 is a basic helix-loop-helix protein, and overexpression of Id2 blocked HIF-1 activation by TGF-β. Furthermore, knockdown of HIF-1 blocked TGF-β-induced apoptosis. Thus, we have identified HIF-1 as a novel mediator downstream of Id2 in the pathway of TGF-β-induced apoptosis." @default.
- W1994422927 created "2016-06-24" @default.
- W1994422927 creator A5006213516 @default.
- W1994422927 creator A5015237902 @default.
- W1994422927 creator A5026692399 @default.
- W1994422927 creator A5027490283 @default.
- W1994422927 creator A5028293886 @default.
- W1994422927 creator A5037119017 @default.
- W1994422927 creator A5049487134 @default.
- W1994422927 creator A5050661957 @default.
- W1994422927 creator A5075404910 @default.
- W1994422927 creator A5079971195 @default.
- W1994422927 date "2009-01-12" @default.
- W1994422927 modified "2023-10-16" @default.
- W1994422927 title "TGF-β repression of Id2 induces apoptosis in gut epithelial cells" @default.
- W1994422927 cites W1622668755 @default.
- W1994422927 cites W1629882101 @default.
- W1994422927 cites W1663371441 @default.
- W1994422927 cites W1998436299 @default.
- W1994422927 cites W2009451238 @default.
- W1994422927 cites W2009522838 @default.
- W1994422927 cites W2009629707 @default.
- W1994422927 cites W2019788712 @default.
- W1994422927 cites W2021741218 @default.
- W1994422927 cites W2024206845 @default.
- W1994422927 cites W2031980124 @default.
- W1994422927 cites W2038449972 @default.
- W1994422927 cites W2040853660 @default.
- W1994422927 cites W2042602894 @default.
- W1994422927 cites W2042773343 @default.
- W1994422927 cites W2044783065 @default.
- W1994422927 cites W2056896643 @default.
- W1994422927 cites W2058152113 @default.
- W1994422927 cites W2059307232 @default.
- W1994422927 cites W2060525294 @default.
- W1994422927 cites W2063076489 @default.
- W1994422927 cites W2069472458 @default.
- W1994422927 cites W2071970475 @default.
- W1994422927 cites W2079849553 @default.
- W1994422927 cites W2087622484 @default.
- W1994422927 cites W2090627731 @default.
- W1994422927 cites W2102526923 @default.
- W1994422927 cites W2103031848 @default.
- W1994422927 cites W2107500412 @default.
- W1994422927 cites W2112247402 @default.
- W1994422927 cites W2115058708 @default.
- W1994422927 cites W2115609800 @default.
- W1994422927 cites W2121836935 @default.
- W1994422927 cites W2137236648 @default.
- W1994422927 cites W2137931232 @default.
- W1994422927 cites W2137956216 @default.
- W1994422927 cites W2141191556 @default.
- W1994422927 cites W2142835688 @default.
- W1994422927 cites W2144264604 @default.
- W1994422927 cites W2172326429 @default.
- W1994422927 doi "https://doi.org/10.1038/onc.2008.456" @default.
- W1994422927 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2943843" @default.
- W1994422927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19137015" @default.
- W1994422927 hasPublicationYear "2009" @default.
- W1994422927 type Work @default.
- W1994422927 sameAs 1994422927 @default.
- W1994422927 citedByCount "38" @default.
- W1994422927 countsByYear W19944229272012 @default.
- W1994422927 countsByYear W19944229272013 @default.
- W1994422927 countsByYear W19944229272014 @default.
- W1994422927 countsByYear W19944229272015 @default.
- W1994422927 countsByYear W19944229272016 @default.
- W1994422927 countsByYear W19944229272017 @default.
- W1994422927 countsByYear W19944229272018 @default.
- W1994422927 countsByYear W19944229272019 @default.
- W1994422927 countsByYear W19944229272020 @default.
- W1994422927 countsByYear W19944229272021 @default.
- W1994422927 countsByYear W19944229272022 @default.
- W1994422927 countsByYear W19944229272023 @default.
- W1994422927 crossrefType "journal-article" @default.
- W1994422927 hasAuthorship W1994422927A5006213516 @default.
- W1994422927 hasAuthorship W1994422927A5015237902 @default.
- W1994422927 hasAuthorship W1994422927A5026692399 @default.
- W1994422927 hasAuthorship W1994422927A5027490283 @default.
- W1994422927 hasAuthorship W1994422927A5028293886 @default.
- W1994422927 hasAuthorship W1994422927A5037119017 @default.
- W1994422927 hasAuthorship W1994422927A5049487134 @default.
- W1994422927 hasAuthorship W1994422927A5050661957 @default.
- W1994422927 hasAuthorship W1994422927A5075404910 @default.
- W1994422927 hasAuthorship W1994422927A5079971195 @default.
- W1994422927 hasBestOaLocation W19944229271 @default.
- W1994422927 hasConcept C104317684 @default.
- W1994422927 hasConcept C118131993 @default.
- W1994422927 hasConcept C153911025 @default.
- W1994422927 hasConcept C170301204 @default.
- W1994422927 hasConcept C173396325 @default.
- W1994422927 hasConcept C190283241 @default.
- W1994422927 hasConcept C2778229498 @default.
- W1994422927 hasConcept C31573885 @default.
- W1994422927 hasConcept C502942594 @default.
- W1994422927 hasConcept C54355233 @default.
- W1994422927 hasConcept C62478195 @default.
- W1994422927 hasConcept C86339819 @default.