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• W1994426412 abstract "Since long-term neuroleptic therapy is known to alter brain dopaminergic sensitivity, we tested the effects of chronic haloperidol administration (10 mg/kg/day for over 3 weeks) on the amount of the dopamine receptors (using 3H-apomorphine and 3H-haloperidol) in various regions of the rat brain. To test whether the changes in dopamine receptors were selectively produced, we also assayed acetylcholine receptors (with 3H-quinuclidinyl benzilate or 3H-QNB), alpha-noradrenergic receptors (with 3H-WB-4101), 3H-serotonin receptors and 3H-naloxone receptors. The specific binding of 3H-haloperidol increased significantly by 34% in the striatum and by 45% in the mesolimbic region after long-term haloperidol. The specific binding of 3H-apomorphine also increased significantly by 77% in the striatum and 55% in the mesolimbic area. Although there was a small significant increase of 20% in specific 3H-serotonin binding in the striatum, no such increment occurred in the hippocampus or the cerebral cortex. No significantly different binding occurred for the other 3H-ligands in these brain regions except for a 13% increase in alpha-noradrenergic binding in the cerebral cortex. These results indicate that long-term haloperidol treatment produces rather selective increases in dopamine/neuroleptic receptors, without much change in 4 other types of receptors. Such relatively selective increments in these receptors may be the basis of dopaminergic supersensitivity (e.g. tardive dyskinesia) after long-term haloperidol." @default.
• W1994426412 created "2016-06-24" @default.
• W1994426412 creator A5005802064 @default.
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• W1994426412 date "1977-12-01" @default.
• W1994426412 modified "2023-09-23" @default.
• W1994426412 title "Brain neurotransmitter receptors after long-term haloperidol: Dopamine, acetylcholine, serotonin, α-noradrenergic and naloxone receptors" @default.
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• W1994426412 doi "https://doi.org/10.1016/0024-3205(77)90155-2" @default.
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