FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994428227> ?p ?o ?g. }

• W1994428227 endingPage "125" @default.
• W1994428227 startingPage "119" @default.
• W1994428227 abstract "The effects of protein kinase A (PKA) mediated phosphorylation on thin filament and cross-bridge function is not fully understood. To delineate the effects of troponin I (TnI) phosphorylation by PKA on contractile protein performance, reconstituted thin filaments were treated with PKA. With the use of the in vitro motility assay, PKA treated thin filament function was assessed relative to non-phosphorylated thin filaments in a calcium-regulated system. At maximal calcium activation, unloaded shortening velocity and force did not differ between the groups. However, at submaximal activation, an increase in calcium sensitivity of the thin filament was observed for velocity but a decrease in calcium sensitivity was observed for force. Activation of the thin filament by myosin strong-binding did not elicit a calcium-independent effect. The rightward shift in calcium sensitivity for force and the leftward shift in calcium sensitivity for velocity indicate that PKA phosphorylation of TnI directly modulates the kinetics of the myosin cross-bridge. In addition, the altered velocity dependence on thin filament length implicates reduced myosin cross-bridge binding with PKA treatment. These data highlight the importance of TnI serine 23 and 24 phosphorylation in the modulation of cardiac function." @default.
• W1994428227 created "2016-06-24" @default.
• W1994428227 creator A5001770808 @default.
• W1994428227 creator A5021858189 @default.
• W1994428227 creator A5022058790 @default.
• W1994428227 creator A5040995148 @default.
• W1994428227 creator A5048446634 @default.
• W1994428227 creator A5089111073 @default.
• W1994428227 date "2005-01-01" @default.
• W1994428227 modified "2023-09-24" @default.
• W1994428227 title "Protein kinase A mediated modulation of acto-myosin kinetics" @default.
• W1994428227 cites W1523578038 @default.
• W1994428227 cites W1539885828 @default.
• W1994428227 cites W1551177506 @default.
• W1994428227 cites W1561116581 @default.
• W1994428227 cites W1593764722 @default.
• W1994428227 cites W1975904377 @default.
• W1994428227 cites W1976445173 @default.
• W1994428227 cites W1978363532 @default.
• W1994428227 cites W1985888641 @default.
• W1994428227 cites W1992491894 @default.
• W1994428227 cites W2007711058 @default.
• W1994428227 cites W2011075985 @default.
• W1994428227 cites W2014534876 @default.
• W1994428227 cites W2025759932 @default.
• W1994428227 cites W2033585364 @default.
• W1994428227 cites W2039159449 @default.
• W1994428227 cites W2039826528 @default.
• W1994428227 cites W2051228751 @default.
• W1994428227 cites W2056840703 @default.
• W1994428227 cites W2065337178 @default.
• W1994428227 cites W2065815391 @default.
• W1994428227 cites W2075321627 @default.
• W1994428227 cites W2076390098 @default.
• W1994428227 cites W2079498453 @default.
• W1994428227 cites W2080477492 @default.
• W1994428227 cites W2085560095 @default.
• W1994428227 cites W2094656982 @default.
• W1994428227 cites W2095532072 @default.
• W1994428227 cites W2103312392 @default.
• W1994428227 cites W2107035208 @default.
• W1994428227 cites W2108990562 @default.
• W1994428227 cites W2131248866 @default.
• W1994428227 cites W2139949573 @default.
• W1994428227 cites W2142693293 @default.
• W1994428227 cites W2144060453 @default.
• W1994428227 cites W2150832969 @default.
• W1994428227 cites W2151808726 @default.
• W1994428227 cites W2157230023 @default.
• W1994428227 cites W2160900044 @default.
• W1994428227 cites W2170565604 @default.
• W1994428227 cites W2185806598 @default.
• W1994428227 cites W2233430209 @default.
• W1994428227 cites W789458867 @default.
• W1994428227 cites W990801113 @default.
• W1994428227 doi "https://doi.org/10.1016/j.yjmcc.2004.10.005" @default.
• W1994428227 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15623428" @default.
• W1994428227 hasPublicationYear "2005" @default.
• W1994428227 type Work @default.
• W1994428227 sameAs 1994428227 @default.
• W1994428227 citedByCount "18" @default.
• W1994428227 countsByYear W19944282272012 @default.
• W1994428227 countsByYear W19944282272014 @default.
• W1994428227 countsByYear W19944282272015 @default.
• W1994428227 countsByYear W19944282272016 @default.
• W1994428227 crossrefType "journal-article" @default.
• W1994428227 hasAuthorship W1994428227A5001770808 @default.
• W1994428227 hasAuthorship W1994428227A5021858189 @default.
• W1994428227 hasAuthorship W1994428227A5022058790 @default.
• W1994428227 hasAuthorship W1994428227A5040995148 @default.
• W1994428227 hasAuthorship W1994428227A5048446634 @default.
• W1994428227 hasAuthorship W1994428227A5089111073 @default.
• W1994428227 hasConcept C11960822 @default.
• W1994428227 hasConcept C12554922 @default.
• W1994428227 hasConcept C125705527 @default.
• W1994428227 hasConcept C14228908 @default.
• W1994428227 hasConcept C178790620 @default.
• W1994428227 hasConcept C185592680 @default.
• W1994428227 hasConcept C519063684 @default.
• W1994428227 hasConcept C55493867 @default.
• W1994428227 hasConcept C6997183 @default.
• W1994428227 hasConcept C8035138 @default.
• W1994428227 hasConcept C86803240 @default.
• W1994428227 hasConcept C97029542 @default.
• W1994428227 hasConceptScore W1994428227C11960822 @default.
• W1994428227 hasConceptScore W1994428227C12554922 @default.
• W1994428227 hasConceptScore W1994428227C125705527 @default.
• W1994428227 hasConceptScore W1994428227C14228908 @default.
• W1994428227 hasConceptScore W1994428227C178790620 @default.
• W1994428227 hasConceptScore W1994428227C185592680 @default.
• W1994428227 hasConceptScore W1994428227C519063684 @default.
• W1994428227 hasConceptScore W1994428227C55493867 @default.
• W1994428227 hasConceptScore W1994428227C6997183 @default.
• W1994428227 hasConceptScore W1994428227C8035138 @default.
• W1994428227 hasConceptScore W1994428227C86803240 @default.
• W1994428227 hasConceptScore W1994428227C97029542 @default.
• W1994428227 hasIssue "1" @default.
• W1994428227 hasLocation W19944282271 @default.

• next