FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994433522> ?p ?o ?g. }

• W1994433522 endingPage "80" @default.
• W1994433522 startingPage "71" @default.
• W1994433522 abstract "Ochratoxin A (OTA) is a mycotoxin produced by fungi of two genera: Penicillium and Aspergillus. OTA has been shown to be nephrotoxic, hepatotoxic, teratogenic, and immunotoxic to several species of animals and to cause kidney and liver tumors in mice and rats. Biotransformation of OTA has not been entirely elucidated. Several metabolites have been characterized in vitro and/or in vivo, whereas other metabolites remain to be characterized. At present, data available regarding OTA metabolism and cytochrome inductions concern only rodents or in vitro systems. The aim of the present study was to explore the effect of OTA on mRNA expression of some cytochromes known to be regulated by pregnane X receptor (PXR), constitutive androstane receptor (CAR), and aryl hydrocarbon receptor (AhR), using primary cultures of human hepatocytes. Our results showed that OTA reduced hepatocyte viability in a dose-dependent manner. Using quantitative real-time reverse-transcription polymerase chain reaction, our study showed that treatment of primary cultured human hepatocytes with noncytotoxic increasing concentrations of OTA for 24 hours caused a significant upregulation of CYP3A4, CYP2B6, and, to a lesser extent, CYP3A5 and CYP2C9. PXR mRNA expression increased in only 1 treated liver, whereas CAR mRNA expression was not affected. OTA was found also to induce an overexpression of CYP1A1 and CYP1A2 genes accompanied by an increase in AhR mRNA expression. These findings suggest that OTA could activate PXR and AhR; however, further investigations are needed to confirm nuclear-receptor activation by OTA." @default.
• W1994433522 created "2016-06-24" @default.
• W1994433522 creator A5009888874 @default.
• W1994433522 creator A5028772377 @default.
• W1994433522 creator A5045870220 @default.
• W1994433522 creator A5046103946 @default.
• W1994433522 creator A5080701253 @default.
• W1994433522 creator A5042363846 @default.
• W1994433522 date "2011-08-11" @default.
• W1994433522 modified "2023-10-11" @default.
• W1994433522 title "Ochratoxin A induces CYP3A4, 2B6, 3A5, 2C9, 1A1, and CYP1A2 gene expression in primary cultured human hepatocytes: a possible activation of nuclear receptors" @default.
• W1994433522 cites W136769219 @default.
• W1994433522 cites W1493232835 @default.
• W1994433522 cites W1502516342 @default.
• W1994433522 cites W1659284631 @default.
• W1994433522 cites W1966836676 @default.
• W1994433522 cites W1967593749 @default.
• W1994433522 cites W1968906511 @default.
• W1994433522 cites W1968906540 @default.
• W1994433522 cites W1976652926 @default.
• W1994433522 cites W1976888074 @default.
• W1994433522 cites W1987856679 @default.
• W1994433522 cites W1991020267 @default.
• W1994433522 cites W1996085200 @default.
• W1994433522 cites W1997271604 @default.
• W1994433522 cites W2000668102 @default.
• W1994433522 cites W2001619915 @default.
• W1994433522 cites W2001645132 @default.
• W1994433522 cites W2002328584 @default.
• W1994433522 cites W2004075793 @default.
• W1994433522 cites W2006998778 @default.
• W1994433522 cites W2008562114 @default.
• W1994433522 cites W2014233887 @default.
• W1994433522 cites W2015716583 @default.
• W1994433522 cites W2016013190 @default.
• W1994433522 cites W2016505105 @default.
• W1994433522 cites W2031241298 @default.
• W1994433522 cites W2032693719 @default.
• W1994433522 cites W2038014794 @default.
• W1994433522 cites W2042763169 @default.
• W1994433522 cites W2043947673 @default.
• W1994433522 cites W2050572437 @default.
• W1994433522 cites W2053774692 @default.
• W1994433522 cites W2061828505 @default.
• W1994433522 cites W2062909696 @default.
• W1994433522 cites W2062953297 @default.
• W1994433522 cites W2065228188 @default.
• W1994433522 cites W2069564134 @default.
• W1994433522 cites W2071357023 @default.
• W1994433522 cites W2073513307 @default.
• W1994433522 cites W2074105606 @default.
• W1994433522 cites W2075082629 @default.
• W1994433522 cites W2077169826 @default.
• W1994433522 cites W2089338956 @default.
• W1994433522 cites W2106566497 @default.
• W1994433522 cites W2109769559 @default.
• W1994433522 cites W2112247582 @default.
• W1994433522 cites W2112563120 @default.
• W1994433522 cites W2114756989 @default.
• W1994433522 cites W2118213045 @default.
• W1994433522 cites W2120467119 @default.
• W1994433522 cites W2120659362 @default.
• W1994433522 cites W2144038328 @default.
• W1994433522 cites W2150946709 @default.
• W1994433522 cites W2155740154 @default.
• W1994433522 cites W2166279203 @default.
• W1994433522 cites W2168336351 @default.
• W1994433522 cites W2171534546 @default.
• W1994433522 cites W2327807854 @default.
• W1994433522 cites W2344683592 @default.
• W1994433522 cites W85081312 @default.
• W1994433522 doi "https://doi.org/10.3109/01480545.2011.589438" @default.
• W1994433522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21834667" @default.
• W1994433522 hasPublicationYear "2011" @default.
• W1994433522 type Work @default.
• W1994433522 sameAs 1994433522 @default.
• W1994433522 citedByCount "21" @default.
• W1994433522 countsByYear W19944335222015 @default.
• W1994433522 countsByYear W19944335222016 @default.
• W1994433522 countsByYear W19944335222017 @default.
• W1994433522 countsByYear W19944335222018 @default.
• W1994433522 countsByYear W19944335222019 @default.
• W1994433522 countsByYear W19944335222020 @default.
• W1994433522 countsByYear W19944335222021 @default.
• W1994433522 crossrefType "journal-article" @default.
• W1994433522 hasAuthorship W1994433522A5009888874 @default.
• W1994433522 hasAuthorship W1994433522A5028772377 @default.
• W1994433522 hasAuthorship W1994433522A5042363846 @default.
• W1994433522 hasAuthorship W1994433522A5045870220 @default.
• W1994433522 hasAuthorship W1994433522A5046103946 @default.
• W1994433522 hasAuthorship W1994433522A5080701253 @default.
• W1994433522 hasConcept C104317684 @default.
• W1994433522 hasConcept C109650736 @default.
• W1994433522 hasConcept C127561419 @default.
• W1994433522 hasConcept C132040763 @default.
• W1994433522 hasConcept C153911025 @default.
• W1994433522 hasConcept C170493617 @default.
• W1994433522 hasConcept C193264327 @default.

• next