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• W1994434812 abstract "No AccessJournal of UrologyPediatric Urology1 Aug 2014Tamsulosin and Spontaneous Passage of Ureteral Stones in Children: A Multi-Institutional Cohort Study Gregory E. Tasian, Nicholas G. Cost, Candace F. Granberg, Jose E. Pulido, Marcelino Rivera, Zeyad Schwen, Marion Schulte, and Janelle A. Fox Gregory E. TasianGregory E. Tasian Department of Surgery, Division of Pediatric Urology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Supported by NIH-T32HD060550. More articles by this author , Nicholas G. CostNicholas G. Cost Department of Surgery, Division of Urology, Colorado Children's Hospital, Denver, Colorado Division of Urology, Cincinnati Children's Hospital, Cincinnati, Ohio More articles by this author , Candace F. GranbergCandace F. Granberg Department of Urology, Mayo Clinic, Rochester, Minnesota More articles by this author , Jose E. PulidoJose E. Pulido Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania More articles by this author , Marcelino RiveraMarcelino Rivera Department of Urology, Mayo Clinic, Rochester, Minnesota More articles by this author , Zeyad SchwenZeyad Schwen University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania More articles by this author , Marion SchulteMarion Schulte Division of Urology, Cincinnati Children's Hospital, Cincinnati, Ohio More articles by this author , and Janelle A. FoxJanelle A. Fox Department of Urology, Naval Medical Center Portsmouth, Portsmouth, Virginia Military service member (or employee of the United States government). This work was prepared as part of official duties. Title 17, USC, §105 provides that “Copyright protection under this title is not available for any work of the U.S. Government.” Title 17, USC, §101 defines a U.S. Government work as a work prepared by a military service member or employee of the U.S. Government as part of that person's official duties. The views expressed in this presentation are those of the author and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense or the United States government. More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.01.091AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Tamsulosin is associated with increased passage of ureteral stones in adults but its effectiveness in children is uncertain. We determined the association between tamsulosin and the spontaneous passage of ureteral stones in children. Materials and Methods: We performed a multi-institutional retrospective cohort study of patients 18 years or younger who presented between 2007 and 2012 with ureteral stones up to 10 mm and who were treated with tamsulosin or oral analgesics alone. The outcome was spontaneous stone passage, defined as radiographic clearance and/or patient report of passage. Subjects prescribed tamsulosin were matched with subjects prescribed analgesics alone, using nearest neighbor propensity score matching to adjust for treatment selection. Conditional logistic regression models were used to estimate the association between tamsulosin and spontaneous passage of ureteral stones, adjusting for stone size and location. Results: Of 449 children with ureteral stones 334 were eligible for inclusion, and complete data were available for 274 patients from 4 institutions (99 receiving tamsulosin, 175 receiving analgesics alone). Following case matching, there were no differences in age, gender, weight, height, stone size or stone location between the 99 subjects prescribed tamsulosin and the 99 propensity score matched subjects prescribed analgesics alone. In the tamsulosin cohort 55% of ureteral stones passed, compared to 44% in the analgesics alone cohort (p = 0.03). In multivariate analysis adjusting for stone size and location tamsulosin was associated with spontaneous passage of ureteral stones (OR 3.31, 95% CI 1.49–7.34). Conclusions: The odds of spontaneous passage of ureteral stones were greater in children prescribed tamsulosin vs analgesics alone. References 1 : Temporal trends in incidence of kidney stones among children: a 25-year population based study. J Urol2012; 188: 247. Link, Google Scholar 2 : Epidemiological trends in pediatric urolithiasis at United States freestanding pediatric hospitals. J Urol2010; 184: 1100. 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Link, Google Scholar © 2014 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byAssimos D (2017) Re: Use of Medical Expulsive Therapy in Children: An Assessment of Nationwide Practice Patterns and OutcomesJournal of Urology, VOL. 199, NO. 1, (22-22), Online publication date: 1-Jan-2018.Shahat A, Elderwy A, Safwat A, Abdelkawi I, Reda A, Abdelsalam Y, Sayed M and Hammouda H (2016) Is Tamsulosin Effective after Shock Wave Lithotripsy for Pediatric Renal Stones? A Randomized, Controlled StudyJournal of Urology, VOL. 195, NO. 4 Part 2, (1284-1288), Online publication date: 1-Apr-2016.Bailey G, Vaughan L, Rose C and Krambeck A (2015) Perinatal Outcomes with Tamsulosin Therapy for Symptomatic UrolithiasisJournal of Urology, VOL. 195, NO. 1, (99-103), Online publication date: 1-Jan-2016.Tasian G and Copelovitch L (2014) Evaluation and Medical Management of Kidney Stones in ChildrenJournal of Urology, VOL. 192, NO. 5, (1329-1336), Online publication date: 1-Nov-2014.Ritchey M (2014) This Month in Pediatric UrologyJournal of Urology, VOL. 192, NO. 2, (293-294), Online publication date: 1-Aug-2014. Volume 192Issue 2August 2014Page: 506-511 Advertisement Copyright & Permissions© 2014 by American Urological Association Education and Research, Inc.Keywordstamsulosinnephrolithiasiscomparative effectiveness researchAcknowledgmentsAngela Kalmus abstracted data for patients seen at Children's Hospital of Philadelphia.MetricsAuthor Information Gregory E. Tasian Department of Surgery, Division of Pediatric Urology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Supported by NIH-T32HD060550. More articles by this author Nicholas G. Cost Department of Surgery, Division of Urology, Colorado Children's Hospital, Denver, Colorado Division of Urology, Cincinnati Children's Hospital, Cincinnati, Ohio More articles by this author Candace F. Granberg Department of Urology, Mayo Clinic, Rochester, Minnesota More articles by this author Jose E. Pulido Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania More articles by this author Marcelino Rivera Department of Urology, Mayo Clinic, Rochester, Minnesota More articles by this author Zeyad Schwen University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania More articles by this author Marion Schulte Division of Urology, Cincinnati Children's Hospital, Cincinnati, Ohio More articles by this author Janelle A. Fox Department of Urology, Naval Medical Center Portsmouth, Portsmouth, Virginia Military service member (or employee of the United States government). This work was prepared as part of official duties. Title 17, USC, §105 provides that “Copyright protection under this title is not available for any work of the U.S. Government.” Title 17, USC, §101 defines a U.S. Government work as a work prepared by a military service member or employee of the U.S. Government as part of that person's official duties. The views expressed in this presentation are those of the author and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense or the United States government. More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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