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- W1994434972 abstract "Functional expression of opioid receptors was detected in the Xenopus oocyte translation system by a voltage-clamp recording. After injection of poly(A)+ RNA isolated from 3-week-old rat striatum or whole brain, the oocytes often demonstrated intracellular Ca2+-mediated oscillatory responsiveness to [d-Ala2, N-methyl-Phe4, Gly5-ol]enkephalin (DAMGO), [d-Pen2, d-Pen5]enkephalin (DPDPE) and U50488H at a concentration of 1 μM. These responses were very transiently expressed after injection of the mRNA, however, water-injected oocytes never responded to any of these opioid agonists. After fractionation by a sucrose-density gradient, an RNA size of about 3–4 kb encoded these opioid receptors. In the oocytes injected with size-selected striatal mRNA, DPDPE evoked the fluctuating current with higher probability and larger amplitude than other agonists, whereas oocytes injected with size-selected whole brain mRNA produced DAMGO and U50488H responses predominantly. The DPDPE response of striatal mRNA-injected oocytes was antagonized by naloxone as well as the δ-specific antagonist ICI 174864. The DAMGO and U50488H responses have not been characterized yet because of a strong desensitizing property making repeated recordings impossible. These observations suggest that putative μ, δ and κ subtypes of opioid receptors mobilizing intracellular Ca2+ are expressed in Xenopus oocytes by rat brain mRNA." @default.
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- W1994434972 date "1994-03-01" @default.
- W1994434972 modified "2023-09-25" @default.
- W1994434972 title "Functional expression of Ca2+-mobilizing opioid receptors in Xenopus oocytes injected with rat brain mRNA" @default.
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- W1994434972 doi "https://doi.org/10.1016/0169-328x(94)90033-7" @default.
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