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- W1994442391 abstract "A regulatory network of G2/M phase transition influenced by different intensities of DNA damage is modeled. It contains the sub-modules of P53-Mdm2 feedback loop and G2/M phase transition process. To investigate the robustness of the regulatory network, a sensitivity analysis of kinetic parameters in the proposed mathematical model is implemented to select the most significant kinetic parameters, which are relevant to key proteins involved in G2/M phase transition. Subsequently, the statistical hypothesis testing is employed to evaluate the influence of perturbations on the G2/M regulatory network. The results indicate that G2/M regulatory network is robust to DNA damage signal when perturbations are very small that is consistent with the experimental observations." @default.
- W1994442391 created "2016-06-24" @default.
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- W1994442391 date "2013-10-01" @default.
- W1994442391 modified "2023-09-26" @default.
- W1994442391 title "A Regulatory Network of G2/M Phase Transition for DNA Damage" @default.
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- W1994442391 doi "https://doi.org/10.4028/www.scientific.net/amm.444-445.1182" @default.
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