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• W1994447535 abstract "Within the tumor microenvironment, IL-6 signaling is generally considered a malevolent player, assuming a dark visage that promotes tumor progression. Chronic IL-6 signaling is linked to tumorigenesis in numerous mouse models as well as in human disease. IL-6 acts intrinsically on tumor cells through numerous downstream mediators to support cancer cell proliferation, survival, and metastatic dissemination. Moreover, IL-6 can act extrinsically on other cells within the complex tumor microenvironment to sustain a pro-tumor milieu by supporting angiogenesis and tumor evasion of immune surveillance. A lesser known role for IL-6 signaling has recently emerged in which it plays a beneficial role, presenting a fairer face that opposes tumor growth by mobilizing anti-tumor T cell immune responses to attain tumor control. Accumulating evidence establishes IL-6 as a key player in the activation, proliferation and survival of lymphocytes during active immune responses. IL-6 signaling can also resculpt the T cell immune response, shifting it from a suppressive to a responsive state that can effectively act against tumors. Finally, IL-6 plays an indispensable role in boosting T cell trafficking to lymph nodes and to tumor sites, where they have the opportunity to become activated and execute their cytotoxic effector functions, respectively. Here, we discuss the dual faces of IL-6 signaling in the tumor microenvironment; the dark face that drives malignancy, and the fairer aspect that promotes anti-tumor adaptive immunity." @default.
• W1994447535 created "2016-06-24" @default.
• W1994447535 creator A5005248918 @default.
• W1994447535 creator A5034794631 @default.
• W1994447535 creator A5064265423 @default.
• W1994447535 date "2014-02-01" @default.
• W1994447535 modified "2023-10-16" @default.
• W1994447535 title "The two faces of IL-6 in the tumor microenvironment" @default.
• W1994447535 cites W1515725948 @default.
• W1994447535 cites W1581761477 @default.
• W1994447535 cites W1597588755 @default.
• W1994447535 cites W1608352853 @default.
• W1994447535 cites W1965037168 @default.
• W1994447535 cites W1969054634 @default.
• W1994447535 cites W1970385958 @default.
• W1994447535 cites W1971091870 @default.
• W1994447535 cites W1971636277 @default.
• W1994447535 cites W1972934671 @default.
• W1994447535 cites W1979540550 @default.
• W1994447535 cites W1982322400 @default.
• W1994447535 cites W1984133971 @default.
• W1994447535 cites W1992912767 @default.
• W1994447535 cites W1993875664 @default.
• W1994447535 cites W1995997868 @default.
• W1994447535 cites W1999300863 @default.
• W1994447535 cites W2001740313 @default.
• W1994447535 cites W2004630197 @default.
• W1994447535 cites W2004714928 @default.
• W1994447535 cites W2006514214 @default.
• W1994447535 cites W2006708761 @default.
• W1994447535 cites W2007268662 @default.
• W1994447535 cites W2007606465 @default.
• W1994447535 cites W2013101093 @default.
• W1994447535 cites W2020350008 @default.
• W1994447535 cites W2024490058 @default.
• W1994447535 cites W2025193872 @default.
• W1994447535 cites W2032835141 @default.
• W1994447535 cites W2034750640 @default.
• W1994447535 cites W2038063798 @default.
• W1994447535 cites W2038479043 @default.
• W1994447535 cites W2042699075 @default.
• W1994447535 cites W2043904711 @default.
• W1994447535 cites W2049491375 @default.
• W1994447535 cites W2049548558 @default.
• W1994447535 cites W2060060625 @default.
• W1994447535 cites W2060672294 @default.
• W1994447535 cites W2063382981 @default.
• W1994447535 cites W2064593553 @default.
• W1994447535 cites W2074299086 @default.
• W1994447535 cites W2074356752 @default.
• W1994447535 cites W2074546881 @default.
• W1994447535 cites W2075117403 @default.
• W1994447535 cites W2076910098 @default.
• W1994447535 cites W2082237689 @default.
• W1994447535 cites W2082626794 @default.
• W1994447535 cites W2097593754 @default.
• W1994447535 cites W2099781464 @default.
• W1994447535 cites W2099805317 @default.
• W1994447535 cites W2100478793 @default.
• W1994447535 cites W2101327682 @default.
• W1994447535 cites W2104849855 @default.
• W1994447535 cites W2110080908 @default.
• W1994447535 cites W2112820219 @default.
• W1994447535 cites W2113702834 @default.
• W1994447535 cites W2114817620 @default.
• W1994447535 cites W2117692326 @default.
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• W1994447535 cites W2120365095 @default.
• W1994447535 cites W2120426523 @default.
• W1994447535 cites W2123105952 @default.
• W1994447535 cites W2128387672 @default.
• W1994447535 cites W2132883099 @default.
• W1994447535 cites W2139520473 @default.
• W1994447535 cites W2148139455 @default.
• W1994447535 cites W2150333647 @default.
• W1994447535 cites W2152181022 @default.
• W1994447535 cites W2152310279 @default.
• W1994447535 cites W2152393981 @default.
• W1994447535 cites W2152765064 @default.
• W1994447535 cites W2157612047 @default.
• W1994447535 cites W2164743896 @default.
• W1994447535 cites W2168631000 @default.
• W1994447535 cites W2169281418 @default.
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• W1994447535 doi "https://doi.org/10.1016/j.smim.2014.01.008" @default.
• W1994447535 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3970580" @default.
• W1994447535 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24602448" @default.
• W1994447535 hasPublicationYear "2014" @default.
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