Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994448950> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1994448950 endingPage "521" @default.
- W1994448950 startingPage "511" @default.
- W1994448950 abstract "A classical (Mendelian) genetic analysis of responses to eight sedative‐hypnotic compounds (ethanol, urethane, trifluoroethanol, chloral hydrate, barbital, paraldehyde, methyprylon, pentobarbital) was conducted in crosses derived from mouse lines that were selectively bred for differential duration of anesthesia following ethanol. The sleep‐time responses of these mice, the long‐sleep (LS) and short‐sleep (SS) mouse lines, as well as the F1, F2 and backcross (F1 × LS, F1 × SS) generations were measured. Generally, differences in responses among the generations were greater for water soluble compounds than were differences for more lipid soluble compounds. Also, the inheritance of responses to water soluble compounds could be explained primarily by additive effects of alleles while the inheritance patterns for more lipid soluble compounds were more complex. Genetic correlation with ethanol response decreased with increasing lipophilicity. These results suggest that the selection of the LS‐SS mouse lines was specific for water soluble anesthetic agents. Because several of these agents are known to act at GABA receptors, examination of the interactions of compounds which differ in lipid solubility at GABA receptors from LS and SS mice may prove useful in elucidating the mechanism of the anesthetic actions of ethanol and other drugs." @default.
- W1994448950 created "2016-06-24" @default.
- W1994448950 creator A5000917351 @default.
- W1994448950 creator A5001238775 @default.
- W1994448950 creator A5027010981 @default.
- W1994448950 creator A5050300076 @default.
- W1994448950 creator A5073849855 @default.
- W1994448950 creator A5089154048 @default.
- W1994448950 date "1992-06-01" @default.
- W1994448950 modified "2023-09-29" @default.
- W1994448950 title "Classical Genetic Analyses of Responses to Sedative-Hypnotic Drugs in Crosses Derived from Long-Sleep and Short-Sleep Mice" @default.
- W1994448950 cites W1495763816 @default.
- W1994448950 cites W1606968589 @default.
- W1994448950 cites W1986949153 @default.
- W1994448950 cites W1992827909 @default.
- W1994448950 cites W2005596604 @default.
- W1994448950 cites W2010972472 @default.
- W1994448950 cites W2025596473 @default.
- W1994448950 cites W2030447351 @default.
- W1994448950 cites W2037675805 @default.
- W1994448950 cites W2049577759 @default.
- W1994448950 cites W2049780185 @default.
- W1994448950 cites W2050885451 @default.
- W1994448950 cites W2054738490 @default.
- W1994448950 cites W2067468321 @default.
- W1994448950 cites W2080927041 @default.
- W1994448950 cites W2081209685 @default.
- W1994448950 cites W2081727202 @default.
- W1994448950 cites W2084534756 @default.
- W1994448950 cites W2107326323 @default.
- W1994448950 cites W2113445369 @default.
- W1994448950 cites W3026678189 @default.
- W1994448950 doi "https://doi.org/10.1111/j.1530-0277.1992.tb01409.x" @default.
- W1994448950 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1352660" @default.
- W1994448950 hasPublicationYear "1992" @default.
- W1994448950 type Work @default.
- W1994448950 sameAs 1994448950 @default.
- W1994448950 citedByCount "14" @default.
- W1994448950 countsByYear W19944489502012 @default.
- W1994448950 crossrefType "journal-article" @default.
- W1994448950 hasAuthorship W1994448950A5000917351 @default.
- W1994448950 hasAuthorship W1994448950A5001238775 @default.
- W1994448950 hasAuthorship W1994448950A5027010981 @default.
- W1994448950 hasAuthorship W1994448950A5050300076 @default.
- W1994448950 hasAuthorship W1994448950A5073849855 @default.
- W1994448950 hasAuthorship W1994448950A5089154048 @default.
- W1994448950 hasConcept C185592680 @default.
- W1994448950 hasConcept C2776755955 @default.
- W1994448950 hasConcept C2777602617 @default.
- W1994448950 hasConcept C2777612814 @default.
- W1994448950 hasConcept C2778162923 @default.
- W1994448950 hasConcept C2780161600 @default.
- W1994448950 hasConcept C2780276229 @default.
- W1994448950 hasConcept C2780930544 @default.
- W1994448950 hasConcept C2910067630 @default.
- W1994448950 hasConcept C42219234 @default.
- W1994448950 hasConcept C55493867 @default.
- W1994448950 hasConcept C71924100 @default.
- W1994448950 hasConcept C86803240 @default.
- W1994448950 hasConcept C98274493 @default.
- W1994448950 hasConceptScore W1994448950C185592680 @default.
- W1994448950 hasConceptScore W1994448950C2776755955 @default.
- W1994448950 hasConceptScore W1994448950C2777602617 @default.
- W1994448950 hasConceptScore W1994448950C2777612814 @default.
- W1994448950 hasConceptScore W1994448950C2778162923 @default.
- W1994448950 hasConceptScore W1994448950C2780161600 @default.
- W1994448950 hasConceptScore W1994448950C2780276229 @default.
- W1994448950 hasConceptScore W1994448950C2780930544 @default.
- W1994448950 hasConceptScore W1994448950C2910067630 @default.
- W1994448950 hasConceptScore W1994448950C42219234 @default.
- W1994448950 hasConceptScore W1994448950C55493867 @default.
- W1994448950 hasConceptScore W1994448950C71924100 @default.
- W1994448950 hasConceptScore W1994448950C86803240 @default.
- W1994448950 hasConceptScore W1994448950C98274493 @default.
- W1994448950 hasIssue "3" @default.
- W1994448950 hasLocation W19944489501 @default.
- W1994448950 hasLocation W19944489502 @default.
- W1994448950 hasOpenAccess W1994448950 @default.
- W1994448950 hasPrimaryLocation W19944489501 @default.
- W1994448950 hasRelatedWork W1965468598 @default.
- W1994448950 hasRelatedWork W1994448950 @default.
- W1994448950 hasRelatedWork W2087923910 @default.
- W1994448950 hasRelatedWork W2102690246 @default.
- W1994448950 hasRelatedWork W2164221591 @default.
- W1994448950 hasRelatedWork W2348095079 @default.
- W1994448950 hasRelatedWork W2367885222 @default.
- W1994448950 hasRelatedWork W2380230879 @default.
- W1994448950 hasRelatedWork W2392373101 @default.
- W1994448950 hasRelatedWork W2398072304 @default.
- W1994448950 hasVolume "16" @default.
- W1994448950 isParatext "false" @default.
- W1994448950 isRetracted "false" @default.
- W1994448950 magId "1994448950" @default.
- W1994448950 workType "article" @default.