FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994450210> ?p ?o ?g. }

• W1994450210 endingPage "100" @default.
• W1994450210 startingPage "95" @default.
• W1994450210 abstract "To characterize extracellular matrix (ECM) and nine matrix metalloproteinase (MMP) changes in two corneas that underwent a complicated laser-assisted in situ keratomileusis (LASIK) procedure.The first patient underwent bilateral LASIK. The flap on the left eye was transected in several locations and placed back. This cornea later developed edema, and the removed flap was analyzed after lamellar keratoplasty. The second patient had a LASIK flap lifted, replaced twice, and then completely removed. The epithelium grew over the stroma, but haze and severe ectasia occurred. After penetrating keratoplasty, the recipient cornea was analyzed. An autopsy cornea from a person who underwent uneventful LASIK and ten normal autopsy corneas served as controls. Corneas were analyzed by immunohistochemistry.Both flap regions in the treated corneas had marked alterations of ECM components and MMPs. Stromal deposits of various ECM proteins, including those normally absent in the central cornea (tenascin-C, fibrillin-1, type XIV collagen), were found. Rare myofibroblasts and inflammatory cells were present. The epithelial basement membrane (BM) was altered in both cases. The most dramatic change was poor or no staining for alpha3-alpha6 type IV collagen chains and thrombospondin. The limbal alpha1-alpha2 type IV collagen and laminin-2 (alpha2beta1gamma1) appeared in the central epithelial BM. Other components were altered to a lesser extent. The anterior stroma was positive for MMP-1 and MMP-2, and some MMP-7 was seen in the epithelium. These ECM and MMP patterns were not seen in uneventful LASIK or normal corneas.In the flaps of LASIK-treated corneas, fibrosed areas of anterior stroma had increased levels of MMP-1 and MMP-2 that may have caused loss of specific type IV collagen isoforms in the epithelial BM. These changes may reflect an ongoing wound healing process and contribute to the development of ectasia." @default.
• W1994450210 created "2016-06-24" @default.
• W1994450210 creator A5007717174 @default.
• W1994450210 creator A5020519188 @default.
• W1994450210 creator A5045792511 @default.
• W1994450210 creator A5061804145 @default.
• W1994450210 creator A5077839390 @default.
• W1994450210 creator A5081739559 @default.
• W1994450210 creator A5083256966 @default.
• W1994450210 date "2002-01-01" @default.
• W1994450210 modified "2023-10-04" @default.
• W1994450210 title "Extracellular Matrix and Matrix Metalloproteinase Changes in Human Corneas After Complicated Laser-Assisted In Situ Keratomileusis (LASIK)" @default.
• W1994450210 cites W1886431664 @default.
• W1994450210 cites W1966148303 @default.
• W1994450210 cites W1978368375 @default.
• W1994450210 cites W2002744139 @default.
• W1994450210 cites W2002768734 @default.
• W1994450210 cites W2044919597 @default.
• W1994450210 cites W2049077785 @default.
• W1994450210 cites W2050344009 @default.
• W1994450210 cites W2050799221 @default.
• W1994450210 cites W2059997101 @default.
• W1994450210 cites W2066471358 @default.
• W1994450210 cites W2068459844 @default.
• W1994450210 cites W2073398350 @default.
• W1994450210 cites W2102450673 @default.
• W1994450210 cites W2119679070 @default.
• W1994450210 cites W2134038721 @default.
• W1994450210 cites W2176205372 @default.
• W1994450210 cites W2186348470 @default.
• W1994450210 cites W2409273613 @default.
• W1994450210 cites W2416212178 @default.
• W1994450210 cites W2430272697 @default.
• W1994450210 cites W2579859616 @default.
• W1994450210 cites W4248565951 @default.
• W1994450210 doi "https://doi.org/10.1097/00003226-200201000-00020" @default.
• W1994450210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11805516" @default.
• W1994450210 hasPublicationYear "2002" @default.
• W1994450210 type Work @default.
• W1994450210 sameAs 1994450210 @default.
• W1994450210 citedByCount "33" @default.
• W1994450210 countsByYear W19944502102013 @default.
• W1994450210 countsByYear W19944502102014 @default.
• W1994450210 countsByYear W19944502102015 @default.
• W1994450210 countsByYear W19944502102016 @default.
• W1994450210 countsByYear W19944502102017 @default.
• W1994450210 countsByYear W19944502102018 @default.
• W1994450210 countsByYear W19944502102021 @default.
• W1994450210 countsByYear W19944502102023 @default.
• W1994450210 crossrefType "journal-article" @default.
• W1994450210 hasAuthorship W1994450210A5007717174 @default.
• W1994450210 hasAuthorship W1994450210A5020519188 @default.
• W1994450210 hasAuthorship W1994450210A5045792511 @default.
• W1994450210 hasAuthorship W1994450210A5061804145 @default.
• W1994450210 hasAuthorship W1994450210A5077839390 @default.
• W1994450210 hasAuthorship W1994450210A5081739559 @default.
• W1994450210 hasAuthorship W1994450210A5083256966 @default.
• W1994450210 hasBestOaLocation W19944502101 @default.
• W1994450210 hasConcept C105702510 @default.
• W1994450210 hasConcept C109523444 @default.
• W1994450210 hasConcept C118487528 @default.
• W1994450210 hasConcept C126322002 @default.
• W1994450210 hasConcept C142724271 @default.
• W1994450210 hasConcept C16930146 @default.
• W1994450210 hasConcept C189165786 @default.
• W1994450210 hasConcept C204232928 @default.
• W1994450210 hasConcept C2776193487 @default.
• W1994450210 hasConcept C2776882836 @default.
• W1994450210 hasConcept C2777107211 @default.
• W1994450210 hasConcept C2777738151 @default.
• W1994450210 hasConcept C2778609529 @default.
• W1994450210 hasConcept C2779814568 @default.
• W1994450210 hasConcept C2780350528 @default.
• W1994450210 hasConcept C52124034 @default.
• W1994450210 hasConcept C529295009 @default.
• W1994450210 hasConcept C71924100 @default.
• W1994450210 hasConcept C86492073 @default.
• W1994450210 hasConcept C86803240 @default.
• W1994450210 hasConcept C95444343 @default.
• W1994450210 hasConceptScore W1994450210C105702510 @default.
• W1994450210 hasConceptScore W1994450210C109523444 @default.
• W1994450210 hasConceptScore W1994450210C118487528 @default.
• W1994450210 hasConceptScore W1994450210C126322002 @default.
• W1994450210 hasConceptScore W1994450210C142724271 @default.
• W1994450210 hasConceptScore W1994450210C16930146 @default.
• W1994450210 hasConceptScore W1994450210C189165786 @default.
• W1994450210 hasConceptScore W1994450210C204232928 @default.
• W1994450210 hasConceptScore W1994450210C2776193487 @default.
• W1994450210 hasConceptScore W1994450210C2776882836 @default.
• W1994450210 hasConceptScore W1994450210C2777107211 @default.
• W1994450210 hasConceptScore W1994450210C2777738151 @default.
• W1994450210 hasConceptScore W1994450210C2778609529 @default.
• W1994450210 hasConceptScore W1994450210C2779814568 @default.
• W1994450210 hasConceptScore W1994450210C2780350528 @default.
• W1994450210 hasConceptScore W1994450210C52124034 @default.
• W1994450210 hasConceptScore W1994450210C529295009 @default.
• W1994450210 hasConceptScore W1994450210C71924100 @default.
• W1994450210 hasConceptScore W1994450210C86492073 @default.

• next