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• W1994451454 startingPage "263" @default.
• W1994451454 abstract "Neurodegenerative patients show often severe everyday decision making problems. Currently it is however not clear which brain atrophy regions are implicated in such decision making problems. We investigated the atrophy correlates of gambling decision making in a sample of 63 participants, including two neurodegenerative conditions (behavioural variant frontotemporal dementia — bvFTD; Alzheimer's disease — AD) as well as healthy age-matched controls. All participants were tested on the Iowa Gambling Task (IGT) and the behavioural IGT results were covaried against the T1 MRI scans of all participants to identify brain atrophy regions implicated in gambling decision making deficits. Our results showed a large variability in IGT performance for all groups with both patient groups performing especially poor on the task. Importantly, bvFTD and AD groups did not differ significantly on the behavioural performance of the IGT. However, by contrast, the atrophy gambling decision making correlates differed between bvFTD and AD, with bvFTD showing more frontal atrophy and AD showing more parietal and temporal atrophy being implicated in decision making deficits, indicating that both patient groups fail the task on different levels. Frontal (frontopolar, anterior cingulate) and parietal (retrosplenial) cortex atrophy covaried with poor performance on the IGT. Taken together, the atrophy correlates of gambling decision making show that such deficits can occur due to a failure of different neural structures, which will inform future diagnostics and treatment options to alleviate these severe everyday problems in neurodegenerative patients." @default.
• W1994451454 created "2016-06-24" @default.
• W1994451454 creator A5064174739 @default.
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• W1994451454 creator A5080229310 @default.
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• W1994451454 date "2013-01-01" @default.
• W1994451454 modified "2023-10-09" @default.
• W1994451454 title "Money for nothing — Atrophy correlates of gambling decision making in behavioural variant frontotemporal dementia and Alzheimer's disease" @default.
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• W1994451454 doi "https://doi.org/10.1016/j.nicl.2013.01.011" @default.
• W1994451454 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3778267" @default.
• W1994451454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24179781" @default.
• W1994451454 hasPublicationYear "2013" @default.
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