FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994462171> ?p ?o ?g. }

• W1994462171 endingPage "73" @default.
• W1994462171 startingPage "65" @default.
• W1994462171 abstract "The effectiveness of ABC has been traditionally measured as the reduction in internal margin (IM) within the planning target volume (PTV). Not to overestimate the benefit of ABC, the effect of patient movement during treatment also needs to be taken into account. We determined the IM and set-up error with ABC and the effect on physical lung parameters compared to standard margins used with free breathing. We also assessed interfraction oesophageal movement to determine a planning organ at risk volume (PRV).Two sequential studies were performed using ABC in NSCLC patients suitable for radical radiotherapy (RT). Twelve out of 14 patients in Study 1 had tumours visible fluoroscopically and had intrafraction tumour movement assessed with and without ABC. Sixteen patients were recruited to Study 2 and had interfraction tumour movement measured using ABC in a moderate deep inspiration breath-hold, of these 7 patients also had interfraction oesophageal movement recorded. Interfraction movement was assessed by CT scan prior to and in the middle and final week of RT. Displacement of the tumour centre of mass and oesophageal borders relative to the first scan provided a measure of movement. Set-up error was measured in 9 patients treated with an in-house lung board adapted for the ABC device. Combining movement and set-up errors determined PTV and PRV margins with ABC. The effect of ABC on mean lung dose (MLD), lung V20 and V13 was calculated.ABC in a moderate deep inspiration breath-hold was tolerated in 25 out of 30 patients (83%) in Study 1 and 2. The random contribution of periodic tumour motion was reduced by 90% in the y direction with ABC compared to free-breathing. The magnitude of motion reduction was less in the x and z direction. Combining the systematic and random set-up error in quadrature with the systematic and random intrafraction and interfraction tumour variations with ABC results in a PTV margin of 8.3mm in the x direction, 12.0mm in the y direction and 9.8mm in the z direction. There was a relative mean reduction in MLD, lung V20 and V13 of 25%, 21% and 18% with the ABC PTV compared to a free-breathing PTV. Oesophageal movement combined with set-up error resulted in an isotropic PRV of 4.7 mm.The reduction in PTV size with ABC resulted in an 18-25% relative reduction in physical lung parameters. PTV margin reduction has the potential to spare normal lung and allow dose-escalation if coupled with image-guided RT. The oesophageal PRV needs to be considered when irradiating central disease and is of increasing importance with altered RT fractionation and concomitant chemoradiation schedules. Further reductions in PTV and PRV may be possible if patient set-up error was minimised, confirming that attention to patient immobilisation is as important as attempts to control tumour motion." @default.
• W1994462171 created "2016-06-24" @default.
• W1994462171 creator A5006634339 @default.
• W1994462171 creator A5010368060 @default.
• W1994462171 creator A5012992427 @default.
• W1994462171 creator A5016927153 @default.
• W1994462171 creator A5018293998 @default.
• W1994462171 creator A5035228430 @default.
• W1994462171 creator A5042722508 @default.
• W1994462171 creator A5046580867 @default.
• W1994462171 creator A5047879448 @default.
• W1994462171 date "2008-04-01" @default.
• W1994462171 modified "2023-10-02" @default.
• W1994462171 title "Defining the margins in the radical radiotherapy of non-small cell lung cancer (NSCLC) with active breathing control (ABC) and the effect on physical lung parameters" @default.
• W1994462171 cites W1944220675 @default.
• W1994462171 cites W1966709141 @default.
• W1994462171 cites W1971950034 @default.
• W1994462171 cites W1973277978 @default.
• W1994462171 cites W1975143516 @default.
• W1994462171 cites W1981797191 @default.
• W1994462171 cites W2005287757 @default.
• W1994462171 cites W2008633691 @default.
• W1994462171 cites W2008726211 @default.
• W1994462171 cites W2016475739 @default.
• W1994462171 cites W2027226834 @default.
• W1994462171 cites W2034655492 @default.
• W1994462171 cites W2035704169 @default.
• W1994462171 cites W2040399379 @default.
• W1994462171 cites W2043189861 @default.
• W1994462171 cites W2044508980 @default.
• W1994462171 cites W2054385160 @default.
• W1994462171 cites W2066230061 @default.
• W1994462171 cites W2068688115 @default.
• W1994462171 cites W2096695475 @default.
• W1994462171 cites W2119298887 @default.
• W1994462171 cites W2122062060 @default.
• W1994462171 cites W2127248382 @default.
• W1994462171 cites W2129591931 @default.
• W1994462171 cites W2134993767 @default.
• W1994462171 cites W2136574784 @default.
• W1994462171 cites W2154462156 @default.
• W1994462171 cites W2167767036 @default.
• W1994462171 cites W2171419394 @default.
• W1994462171 cites W4239714259 @default.
• W1994462171 cites W4256222744 @default.
• W1994462171 doi "https://doi.org/10.1016/j.radonc.2007.12.012" @default.
• W1994462171 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18267345" @default.
• W1994462171 hasPublicationYear "2008" @default.
• W1994462171 type Work @default.
• W1994462171 sameAs 1994462171 @default.
• W1994462171 citedByCount "73" @default.
• W1994462171 countsByYear W19944621712012 @default.
• W1994462171 countsByYear W19944621712013 @default.
• W1994462171 countsByYear W19944621712014 @default.
• W1994462171 countsByYear W19944621712015 @default.
• W1994462171 countsByYear W19944621712016 @default.
• W1994462171 countsByYear W19944621712017 @default.
• W1994462171 countsByYear W19944621712018 @default.
• W1994462171 countsByYear W19944621712019 @default.
• W1994462171 countsByYear W19944621712020 @default.
• W1994462171 countsByYear W19944621712021 @default.
• W1994462171 countsByYear W19944621712022 @default.
• W1994462171 countsByYear W19944621712023 @default.
• W1994462171 crossrefType "journal-article" @default.
• W1994462171 hasAuthorship W1994462171A5006634339 @default.
• W1994462171 hasAuthorship W1994462171A5010368060 @default.
• W1994462171 hasAuthorship W1994462171A5012992427 @default.
• W1994462171 hasAuthorship W1994462171A5016927153 @default.
• W1994462171 hasAuthorship W1994462171A5018293998 @default.
• W1994462171 hasAuthorship W1994462171A5035228430 @default.
• W1994462171 hasAuthorship W1994462171A5042722508 @default.
• W1994462171 hasAuthorship W1994462171A5046580867 @default.
• W1994462171 hasAuthorship W1994462171A5047879448 @default.
• W1994462171 hasBestOaLocation W19944621712 @default.
• W1994462171 hasConcept C126322002 @default.
• W1994462171 hasConcept C126838900 @default.
• W1994462171 hasConcept C27101514 @default.
• W1994462171 hasConcept C2776256026 @default.
• W1994462171 hasConcept C2777714996 @default.
• W1994462171 hasConcept C2989005 @default.
• W1994462171 hasConcept C39300077 @default.
• W1994462171 hasConcept C42219234 @default.
• W1994462171 hasConcept C509974204 @default.
• W1994462171 hasConcept C71924100 @default.
• W1994462171 hasConceptScore W1994462171C126322002 @default.
• W1994462171 hasConceptScore W1994462171C126838900 @default.
• W1994462171 hasConceptScore W1994462171C27101514 @default.
• W1994462171 hasConceptScore W1994462171C2776256026 @default.
• W1994462171 hasConceptScore W1994462171C2777714996 @default.
• W1994462171 hasConceptScore W1994462171C2989005 @default.
• W1994462171 hasConceptScore W1994462171C39300077 @default.
• W1994462171 hasConceptScore W1994462171C42219234 @default.
• W1994462171 hasConceptScore W1994462171C509974204 @default.
• W1994462171 hasConceptScore W1994462171C71924100 @default.
• W1994462171 hasIssue "1" @default.
• W1994462171 hasLocation W19944621711 @default.
• W1994462171 hasLocation W19944621712 @default.
• W1994462171 hasLocation W19944621713 @default.

• next