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- W1994464390 abstract "The influence of diazepam on the disposition of intracisternally injected serotonin-C14 (5-HT-C14) was studied in the rat. Pretreatment with diazepam failed to affect the uptake of this monoamine into brain. Whole brain levels of 5-HT-C14 and 5-hydroxyindoleacetic acid-C14 (5-HIAA-C14), substantially above control levels, were found in diazepam-treated rats killed three hours after 5-HT-C14 administration. The drug markedly retarded the efflux of intracisternally administered 5-HIAA-C14 but had no effect on metaraminol-H3, a monoamine which is not metabolized in brain. These findings suggest that diazepam may act on mechanisms subserving the transport of 5-HIAA from brain as well as on the cerebral metabolism of 5-HT." @default.
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- W1994464390 title "Effect of diazepam on fate of intracisternally injected serotonin-C14" @default.
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- W1994464390 doi "https://doi.org/10.1016/0028-3908(70)90053-5" @default.
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