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- W1994469778 abstract "The synthesis of (1R)-1-acetamido-2-(3-carboxyphenyl)ethane boronic acid , a rationally designed transition state analog competitive inhibitor of the RTEM-1 β-lactamase from Escherichia coli, is reported Kinetic measurements show that, as designed, it is a highly effective reversible inhibitor of the β-lactamase, with an inhibition constant of 110 nM This is the most potent competitive inhibitor of a β-lactamase yet reported." @default.
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- W1994469778 date "1995-11-01" @default.
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- W1994469778 title "Rational design and synthesis of a highly effective transition state analog inhibitor of the RTEM-1 β-lactamase" @default.
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- W1994469778 doi "https://doi.org/10.1016/0040-4039(95)01799-n" @default.
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