FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994472094> ?p ?o ?g. }

• W1994472094 endingPage "500" @default.
• W1994472094 startingPage "492" @default.
• W1994472094 abstract "The citrin/mitochondrial glycerol-3-phosphate dehydrogenase (mGPD) double-knockout mouse displays phenotypic attributes of both neonatal intrahepatic cholestasis and adult-onset type II citrullinemia, making it a suitable model of human citrin deficiency. In the present study, we investigated metabolic disturbances in the livers of wild-type, citrin (Ctrn) knockout, mGPD knockout, and Ctrn/mGPD double-knockout mice following oral sucrose versus saline administration using metabolomic approaches. By using gas chromatography/mass spectrometry and capillary electrophoresis/mass spectrometry, we found three general groupings of metabolite changes in the livers of the double-knockout mice following sucrose administration that were subsequently confirmed using liquid chromatography/mass spectrometry or enzymatic methods: a marked increase of hepatic glycerol 3-phosphate, a generalized decrease of hepatic tricarboxylic acid cycle intermediates, and alterations of hepatic amino acid levels related to the urea cycle or lysine catabolism including marked increases in citrulline and lysine. Furthermore, concurrent oral administration of sodium pyruvate with sucrose ameliorated the hyperammonemia induced by sucrose, as had been shown previously, as well as almost completely normalizing the hepatic metabolite perturbations found. Overall, we have identified additional metabolic disturbances in double-KO mice following oral sucrose administration, and provided further evidence for the therapeutic use of sodium pyruvate in our mouse model of citrin deficiency." @default.
• W1994472094 created "2016-06-24" @default.
• W1994472094 creator A5002254691 @default.
• W1994472094 creator A5003322473 @default.
• W1994472094 creator A5025837026 @default.
• W1994472094 creator A5032353188 @default.
• W1994472094 creator A5033262596 @default.
• W1994472094 creator A5040548657 @default.
• W1994472094 creator A5041674724 @default.
• W1994472094 creator A5057769049 @default.
• W1994472094 creator A5061424329 @default.
• W1994472094 creator A5072477482 @default.
• W1994472094 creator A5075334923 @default.
• W1994472094 creator A5080920020 @default.
• W1994472094 creator A5087660536 @default.
• W1994472094 date "2011-12-01" @default.
• W1994472094 modified "2023-10-17" @default.
• W1994472094 title "Metabolomic analysis reveals hepatic metabolite perturbations in citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mice, a model of human citrin deficiency" @default.
• W1994472094 cites W100983753 @default.
• W1994472094 cites W1511074013 @default.
• W1994472094 cites W1608709490 @default.
• W1994472094 cites W1954237778 @default.
• W1994472094 cites W1985345221 @default.
• W1994472094 cites W1986211872 @default.
• W1994472094 cites W1987344031 @default.
• W1994472094 cites W1995313730 @default.
• W1994472094 cites W1999409415 @default.
• W1994472094 cites W2010594727 @default.
• W1994472094 cites W2011037803 @default.
• W1994472094 cites W2012713414 @default.
• W1994472094 cites W2013215206 @default.
• W1994472094 cites W2016844315 @default.
• W1994472094 cites W2029763798 @default.
• W1994472094 cites W2035280267 @default.
• W1994472094 cites W2037267603 @default.
• W1994472094 cites W2044541853 @default.
• W1994472094 cites W2045839188 @default.
• W1994472094 cites W2064759446 @default.
• W1994472094 cites W2068435170 @default.
• W1994472094 cites W2074936221 @default.
• W1994472094 cites W2081798490 @default.
• W1994472094 cites W2104640608 @default.
• W1994472094 cites W2108847729 @default.
• W1994472094 cites W2122784758 @default.
• W1994472094 cites W2124470505 @default.
• W1994472094 cites W2133002620 @default.
• W1994472094 cites W2140564760 @default.
• W1994472094 cites W2142089485 @default.
• W1994472094 cites W2142124828 @default.
• W1994472094 cites W2149212516 @default.
• W1994472094 cites W2155395690 @default.
• W1994472094 cites W2281343124 @default.
• W1994472094 doi "https://doi.org/10.1016/j.ymgme.2011.08.015" @default.
• W1994472094 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21908222" @default.
• W1994472094 hasPublicationYear "2011" @default.
• W1994472094 type Work @default.
• W1994472094 sameAs 1994472094 @default.
• W1994472094 citedByCount "31" @default.
• W1994472094 countsByYear W19944720942012 @default.
• W1994472094 countsByYear W19944720942013 @default.
• W1994472094 countsByYear W19944720942014 @default.
• W1994472094 countsByYear W19944720942015 @default.
• W1994472094 countsByYear W19944720942016 @default.
• W1994472094 countsByYear W19944720942017 @default.
• W1994472094 countsByYear W19944720942018 @default.
• W1994472094 countsByYear W19944720942019 @default.
• W1994472094 countsByYear W19944720942020 @default.
• W1994472094 countsByYear W19944720942021 @default.
• W1994472094 crossrefType "journal-article" @default.
• W1994472094 hasAuthorship W1994472094A5002254691 @default.
• W1994472094 hasAuthorship W1994472094A5003322473 @default.
• W1994472094 hasAuthorship W1994472094A5025837026 @default.
• W1994472094 hasAuthorship W1994472094A5032353188 @default.
• W1994472094 hasAuthorship W1994472094A5033262596 @default.
• W1994472094 hasAuthorship W1994472094A5040548657 @default.
• W1994472094 hasAuthorship W1994472094A5041674724 @default.
• W1994472094 hasAuthorship W1994472094A5057769049 @default.
• W1994472094 hasAuthorship W1994472094A5061424329 @default.
• W1994472094 hasAuthorship W1994472094A5072477482 @default.
• W1994472094 hasAuthorship W1994472094A5075334923 @default.
• W1994472094 hasAuthorship W1994472094A5080920020 @default.
• W1994472094 hasAuthorship W1994472094A5087660536 @default.
• W1994472094 hasConcept C126322002 @default.
• W1994472094 hasConcept C135870905 @default.
• W1994472094 hasConcept C165135838 @default.
• W1994472094 hasConcept C170493617 @default.
• W1994472094 hasConcept C182704531 @default.
• W1994472094 hasConcept C185592680 @default.
• W1994472094 hasConcept C21565614 @default.
• W1994472094 hasConcept C2776580952 @default.
• W1994472094 hasConcept C2777468819 @default.
• W1994472094 hasConcept C2777477808 @default.
• W1994472094 hasConcept C2777535116 @default.
• W1994472094 hasConcept C2778597767 @default.
• W1994472094 hasConcept C2781099255 @default.
• W1994472094 hasConcept C43617362 @default.
• W1994472094 hasConcept C515207424 @default.
• W1994472094 hasConcept C55493867 @default.

• next