FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994472314> ?p ?o ?g. }

• W1994472314 endingPage "11603" @default.
• W1994472314 startingPage "11593" @default.
• W1994472314 abstract "High levels of viral replication occur in gut-associated lymphoid tissue (GALT) and other lymphoid tissues (LT) since the early phase of human/simian immunodeficiency virus (HIV/SIV) infection. Regulatory T cells (T(reg)), a subset of immunosuppressive T cells expressing CTLA-4 and the FoxP3 transcription factor, accumulate in LT during HIV/SIV infection. Here we show that FoxP3 and CTLA-4 mRNA are increased in leukocytes from the spleens, lymph nodes (LN), and mucosal sites of chronically SIV-infected macaques with high viremia (SIV(HI)) compared to animals with low viremia (SIV(LO)). FoxP3 and CTLA-4 correlated with SIV RNA levels in tissues; SIV virus levels in the spleen, inguinal LN, mesenteric LN, colon, and jejunum directly correlated with the plasma virus level. Importantly, CTLA-4 and FoxP3 mRNA were predominantly increased in the CD25(-) subpopulation of leukocytes from SIV(HI), further challenging the classical definition of T(reg) as CD4(+) CD25(+) T cells. Similar to CTLA-4 and FoxP3, expression of indoleamine 2,3-dioxygenase (IDO), an immunosuppressive enzyme induced by T(reg) in antigen-presenting cells, was increased in the spleens, mesenteric LN, colons, and jejuna from SIV(HI) compared to SIV(LO) and directly correlated to SIV RNA in the same tissues. Accordingly, plasma kynurenine/tryptophan, a marker for IDO enzymatic activity, was significantly higher in SIV(HI) compared to SIV(LO) and correlated with plasma viral levels. Increased T(reg) and IDO in LT of SIV-infected macaques may be the consequence of increased tissue inflammation and/or may favor virus replication during the chronic phase of SIV infection." @default.
• W1994472314 created "2016-06-24" @default.
• W1994472314 creator A5004374605 @default.
• W1994472314 creator A5018768648 @default.
• W1994472314 creator A5055963852 @default.
• W1994472314 creator A5057232035 @default.
• W1994472314 creator A5057365611 @default.
• W1994472314 creator A5064542288 @default.
• W1994472314 creator A5081156604 @default.
• W1994472314 creator A5082622248 @default.
• W1994472314 creator A5082750234 @default.
• W1994472314 creator A5083601720 @default.
• W1994472314 date "2007-11-01" @default.
• W1994472314 modified "2023-10-06" @default.
• W1994472314 title "Regulatory T-Cell Markers, Indoleamine 2,3-Dioxygenase, and Virus Levels in Spleen and Gut during Progressive Simian Immunodeficiency Virus Infection" @default.
• W1994472314 cites W1591814377 @default.
• W1994472314 cites W1801247541 @default.
• W1994472314 cites W1925988920 @default.
• W1994472314 cites W1947375451 @default.
• W1994472314 cites W1966656379 @default.
• W1994472314 cites W1968276891 @default.
• W1994472314 cites W1975929837 @default.
• W1994472314 cites W1977276034 @default.
• W1994472314 cites W1983626365 @default.
• W1994472314 cites W1984999783 @default.
• W1994472314 cites W1988527234 @default.
• W1994472314 cites W1988941798 @default.
• W1994472314 cites W1993002158 @default.
• W1994472314 cites W1993051112 @default.
• W1994472314 cites W1999028733 @default.
• W1994472314 cites W1999396723 @default.
• W1994472314 cites W2004708987 @default.
• W1994472314 cites W2004998289 @default.
• W1994472314 cites W2008994596 @default.
• W1994472314 cites W2028889518 @default.
• W1994472314 cites W2030605921 @default.
• W1994472314 cites W2030606999 @default.
• W1994472314 cites W2037920661 @default.
• W1994472314 cites W2042985653 @default.
• W1994472314 cites W2049378286 @default.
• W1994472314 cites W2067695164 @default.
• W1994472314 cites W2076120354 @default.
• W1994472314 cites W2084744825 @default.
• W1994472314 cites W2090067693 @default.
• W1994472314 cites W2096423439 @default.
• W1994472314 cites W2097811455 @default.
• W1994472314 cites W2131466396 @default.
• W1994472314 cites W2132926599 @default.
• W1994472314 cites W2133277136 @default.
• W1994472314 cites W2135698322 @default.
• W1994472314 cites W2135816279 @default.
• W1994472314 cites W2139155483 @default.
• W1994472314 cites W2139194252 @default.
• W1994472314 cites W2146934919 @default.
• W1994472314 cites W2150484278 @default.
• W1994472314 cites W2154280336 @default.
• W1994472314 cites W2155506409 @default.
• W1994472314 cites W2156286595 @default.
• W1994472314 cites W2171377694 @default.
• W1994472314 cites W2175273487 @default.
• W1994472314 cites W220755940 @default.
• W1994472314 cites W2409536556 @default.
• W1994472314 cites W2417051390 @default.
• W1994472314 cites W2737785069 @default.
• W1994472314 cites W6527825 @default.
• W1994472314 doi "https://doi.org/10.1128/jvi.00760-07" @default.
• W1994472314 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2168803" @default.
• W1994472314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17715231" @default.
• W1994472314 hasPublicationYear "2007" @default.
• W1994472314 type Work @default.
• W1994472314 sameAs 1994472314 @default.
• W1994472314 citedByCount "102" @default.
• W1994472314 countsByYear W19944723142012 @default.
• W1994472314 countsByYear W19944723142013 @default.
• W1994472314 countsByYear W19944723142014 @default.
• W1994472314 countsByYear W19944723142015 @default.
• W1994472314 countsByYear W19944723142016 @default.
• W1994472314 countsByYear W19944723142017 @default.
• W1994472314 countsByYear W19944723142018 @default.
• W1994472314 countsByYear W19944723142019 @default.
• W1994472314 countsByYear W19944723142020 @default.
• W1994472314 countsByYear W19944723142021 @default.
• W1994472314 crossrefType "journal-article" @default.
• W1994472314 hasAuthorship W1994472314A5004374605 @default.
• W1994472314 hasAuthorship W1994472314A5018768648 @default.
• W1994472314 hasAuthorship W1994472314A5055963852 @default.
• W1994472314 hasAuthorship W1994472314A5057232035 @default.
• W1994472314 hasAuthorship W1994472314A5057365611 @default.
• W1994472314 hasAuthorship W1994472314A5064542288 @default.
• W1994472314 hasAuthorship W1994472314A5081156604 @default.
• W1994472314 hasAuthorship W1994472314A5082622248 @default.
• W1994472314 hasAuthorship W1994472314A5082750234 @default.
• W1994472314 hasAuthorship W1994472314A5083601720 @default.
• W1994472314 hasBestOaLocation W19944723142 @default.
• W1994472314 hasConcept C142462285 @default.
• W1994472314 hasConcept C159047783 @default.
• W1994472314 hasConcept C181152851 @default.
• W1994472314 hasConcept C203014093 @default.

• next