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• W1994477876 abstract "Background: Protease inhibitor (PI)-containing regimens have led to improved survival among HIV-infected children. However, adverse effects, including dyslipidemia, may put children at risk for cardiovascular disease. Methods: Serum cholesterol and triglyceride levels were recorded on perinatally HIV-infected children participating in the PACTS-HOPE cohort (1999-2004). Hypercholesterolemia (HC) was defined as cholesterol ≥200 mg/dL and hypertriglyceridemia (HT) as triglycerides ≥150 mg/dL. HC and HT were modeled over time using generalized estimating equations. Results: For 178 children, 47% met criteria for HC and 67% for HT at least once during the study period. In generalized estimating equation models, PI use, undetectable viral load, and immunologic category 3 were independent predictors of HC. HT was significantly associated with PI use and body mass index (BMI) ≥90th percentile for age and gender. Among children on PI-containing regimens, HC was significantly associated with multiple PIs and undetectable viral load; HT was predicted by body mass index ≥90th percentile and ritonavir use. The prevalence of clinical lipodystrophy was 5.6% (10/178). Conclusions: Children on PI-containing regimens have a higher risk of both HC and HT. Lipid levels should be measured regularly in children on antiretroviral treatment. Interventions such as diet, exercise, or lipid-lowering drug therapy may benefit some children." @default.
• W1994477876 created "2016-06-24" @default.
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• W1994477876 date "2006-04-01" @default.
• W1994477876 modified "2023-10-14" @default.
• W1994477876 title "Dyslipidemia Among Perinatally HIV-Infected Children Enrolled in the PACTS-HOPE Cohort, 1999-2004" @default.
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• W1994477876 doi "https://doi.org/10.1097/01.qai.0000218344.88304.db" @default.
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