Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994483949> ?p ?o ?g. }
- W1994483949 endingPage "851" @default.
- W1994483949 startingPage "842" @default.
- W1994483949 abstract "alpha(1)-Microglobulin is a 26-kDa glycoprotein synthesized in the liver, secreted to the blood, and rapidly distributed to the extravascular compartment of all tissues. Recent results show that alpha(1)-microglobulin has heme-binding and heme-degrading properties and it has been suggested that the protein is involved in the defense against oxidation by heme and reactive oxygen species. In the present study the influence of hemoglobin and reactive oxygen species (ROS) on the cellular expression of alpha(1)-microglobulin was investigated. Oxy- and methemoglobin, free heme, and Fenton reaction-induced hydroxyl radicals induced a dose-dependent up-regulation of alpha(1)-microglobulin on both mRNA and protein levels in hepatoma cells and an increased secretion of alpha(1)-microglobulin. The up-regulation was reversed by the addition of catalase and ascorbate, and by reacting hemoglobin with cyanide which prevents redox reactions. Furthermore, the blood cell lines U937 and K562 expressed alpha(1)-microglobulin at low levels, and this expression increased up to 11-fold by the addition of hemoglobin. These results suggest that alpha(1)-microglobulin expression is induced by ROS, arising from redox reactions of hemoglobin or from other sources and are consistent with the hypothesis that alpha(1)-microglobulin participates in the defense against oxidation by hemoglobin, heme, and reactive oxygen species." @default.
- W1994483949 created "2016-06-24" @default.
- W1994483949 creator A5038829375 @default.
- W1994483949 creator A5041902578 @default.
- W1994483949 creator A5045155025 @default.
- W1994483949 creator A5047246047 @default.
- W1994483949 date "2007-03-01" @default.
- W1994483949 modified "2023-10-16" @default.
- W1994483949 title "Up-regulation of α1-microglobulin by hemoglobin and reactive oxygen species in hepatoma and blood cell lines" @default.
- W1994483949 cites W1496699014 @default.
- W1994483949 cites W1498470436 @default.
- W1994483949 cites W1564991378 @default.
- W1994483949 cites W1599883989 @default.
- W1994483949 cites W1602700702 @default.
- W1994483949 cites W1634873152 @default.
- W1994483949 cites W1778242725 @default.
- W1994483949 cites W1798026767 @default.
- W1994483949 cites W1893651774 @default.
- W1994483949 cites W1932052686 @default.
- W1994483949 cites W1966030183 @default.
- W1994483949 cites W1969352100 @default.
- W1994483949 cites W1977893875 @default.
- W1994483949 cites W1982572094 @default.
- W1994483949 cites W1987815751 @default.
- W1994483949 cites W1990440844 @default.
- W1994483949 cites W1990838236 @default.
- W1994483949 cites W2003197904 @default.
- W1994483949 cites W2007954089 @default.
- W1994483949 cites W2009809359 @default.
- W1994483949 cites W2021158705 @default.
- W1994483949 cites W2025339373 @default.
- W1994483949 cites W2027848571 @default.
- W1994483949 cites W2033256958 @default.
- W1994483949 cites W2040141270 @default.
- W1994483949 cites W2042956894 @default.
- W1994483949 cites W2048086807 @default.
- W1994483949 cites W2049002898 @default.
- W1994483949 cites W2052827870 @default.
- W1994483949 cites W2061228574 @default.
- W1994483949 cites W2061971880 @default.
- W1994483949 cites W2073087806 @default.
- W1994483949 cites W2074403325 @default.
- W1994483949 cites W2075728087 @default.
- W1994483949 cites W2081748503 @default.
- W1994483949 cites W2082092043 @default.
- W1994483949 cites W2083352116 @default.
- W1994483949 cites W2086520187 @default.
- W1994483949 cites W2095477436 @default.
- W1994483949 cites W2100837269 @default.
- W1994483949 cites W2101861123 @default.
- W1994483949 cites W2117189019 @default.
- W1994483949 cites W2120918205 @default.
- W1994483949 cites W2127223050 @default.
- W1994483949 cites W2140830096 @default.
- W1994483949 cites W2154043385 @default.
- W1994483949 cites W2229460713 @default.
- W1994483949 cites W37543886 @default.
- W1994483949 cites W4313305959 @default.
- W1994483949 cites W1574332573 @default.
- W1994483949 doi "https://doi.org/10.1016/j.freeradbiomed.2006.12.017" @default.
- W1994483949 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17320766" @default.
- W1994483949 hasPublicationYear "2007" @default.
- W1994483949 type Work @default.
- W1994483949 sameAs 1994483949 @default.
- W1994483949 citedByCount "47" @default.
- W1994483949 countsByYear W19944839492012 @default.
- W1994483949 countsByYear W19944839492013 @default.
- W1994483949 countsByYear W19944839492014 @default.
- W1994483949 countsByYear W19944839492015 @default.
- W1994483949 countsByYear W19944839492016 @default.
- W1994483949 countsByYear W19944839492017 @default.
- W1994483949 countsByYear W19944839492018 @default.
- W1994483949 countsByYear W19944839492019 @default.
- W1994483949 countsByYear W19944839492020 @default.
- W1994483949 countsByYear W19944839492021 @default.
- W1994483949 countsByYear W19944839492022 @default.
- W1994483949 crossrefType "journal-article" @default.
- W1994483949 hasAuthorship W1994483949A5038829375 @default.
- W1994483949 hasAuthorship W1994483949A5041902578 @default.
- W1994483949 hasAuthorship W1994483949A5045155025 @default.
- W1994483949 hasAuthorship W1994483949A5047246047 @default.
- W1994483949 hasBestOaLocation W19944839492 @default.
- W1994483949 hasConcept C153911025 @default.
- W1994483949 hasConcept C178790620 @default.
- W1994483949 hasConcept C179104552 @default.
- W1994483949 hasConcept C181199279 @default.
- W1994483949 hasConcept C185592680 @default.
- W1994483949 hasConcept C203014093 @default.
- W1994483949 hasConcept C20705724 @default.
- W1994483949 hasConcept C21957315 @default.
- W1994483949 hasConcept C26865036 @default.
- W1994483949 hasConcept C2776151105 @default.
- W1994483949 hasConcept C2776217839 @default.
- W1994483949 hasConcept C2778917026 @default.
- W1994483949 hasConcept C2778979269 @default.
- W1994483949 hasConcept C48349386 @default.
- W1994483949 hasConcept C540031477 @default.
- W1994483949 hasConcept C55493867 @default.