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• W1994484253 abstract "A phospholipase A2-containing fraction was isolated from the venom of Bothrops insularis by a combination of gel filtration on Sephadex G-150 and ion exchange chromatography on DEAE-Sephadex. Peak IV of the latter chromatography containing all of the phospholipase A2 (PLA2) activity, was assayed on isolated neuromuscular preparations. In the mouse phrenic nerve-diaphragm incubated in Tyrode at 37°C, the PLA2 fraction produced an initial increase in the twitch tension and in the frequency of the mepps, followed by a dose-dependent, irreversible blockade. The replacement of 1.8 mM Ca2+ by 4 mM Sr2+ inhibited the neuromuscular blocking effect of the fraction. In the chick biventer cervicis preparation incubated with Krebs solution at 37°C, the PLA2 fraction induced blockade but did not affect the response to acetylcholine and K+, excluding the involvement of post-synaptic and direct muscular effects. A low temperature (18–22°C) incubation prevented the neuromuscular effect from developing. These results suggest that the PLA2-containing fraction acts predominantly at presynaptic sites at the neuromuscular junction. This fraction also accounts for most of the pharmacological effects of the crude venom." @default.
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• W1994484253 date "1998-10-01" @default.
• W1994484253 modified "2023-10-01" @default.
• W1994484253 title "An unusual presynaptic action of Bothrops insularis snake venom mediated by phospholipase A2 fraction" @default.
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• W1994484253 doi "https://doi.org/10.1016/s0041-0101(97)00174-8" @default.
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