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• W1994485491 abstract "I congratulate Mostafa et al. on their findings that there is a strong association between oxidative stress and autoimmunity in autism. They suggest the possible role of antioxidants and immunotherapy in the treatment of autism ( Mostafa et al., 2010 Mostafa G.A. El-Hadidi E.S. et al. Oxidative stress in Egyptian children with autism: relation to autoimmunity. J. Neuroimmunol. 2010; 219: 114-118 Abstract Full Text Full Text PDF PubMed Scopus (86) Google Scholar ). “Indeed, recent studies have emphasized the role of elevated plasma cytokines in autism spectrum disorders ( Ashwood et al., 2010 Ashwood P. Krakowiak P. et al. Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome.. Brain Behav. Immun. 2010; (Aug 10, Electronic publication ahead of print) Google Scholar ), and inflammation has been associated with stereotypy in autism ( Ashwood et al., 2010 Ashwood P. Krakowiak P. et al. Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome.. Brain Behav. Immun. 2010; (Aug 10, Electronic publication ahead of print) Google Scholar ). However, it is currently unclear how inflammation and immunity could affect stereotypical behaviors in autism spectrum disorders ( Ashwood et al., 2010 Ashwood P. Krakowiak P. et al. Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome.. Brain Behav. Immun. 2010; (Aug 10, Electronic publication ahead of print) Google Scholar ). In addition, the neurobiology of stereotypy is poorly understood ( Korff et al., 2009 Korff S. Stein D.J. et al. Cortico-striatal cyclic AMP-phosphodiesterase-4 signalling and stereotypy in the deer mouse: attenuation after chronic fluoxetine treatment. Pharmacol. Biochem. Behav. 2009; 92: 514-520 Crossref PubMed Scopus (27) Google Scholar ). Herein, I propose that there is an association between oxidative stress and autoimmunity in autism ( Mostafa et al., 2010 Mostafa G.A. El-Hadidi E.S. et al. Oxidative stress in Egyptian children with autism: relation to autoimmunity. J. Neuroimmunol. 2010; 219: 114-118 Abstract Full Text Full Text PDF PubMed Scopus (86) Google Scholar ), thus providing a possible novel explanation for the association of the role of the immune response and stereotypy in autism. Then, its possible research and clinical implications are suggested." @default.
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• W1994485491 date "2011-03-01" @default.
• W1994485491 modified "2023-09-27" @default.
• W1994485491 title "Oxidative stress may mediate association of stereotypy and immunity in autism, a novel explanation with clinical and research implications" @default.
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• W1994485491 doi "https://doi.org/10.1016/j.jneuroim.2010.10.005" @default.
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