FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994501461> ?p ?o ?g. }

• W1994501461 abstract "Abstract Research into lipoprotein metabolism has developed because understanding lipoprotein metabolism has important clinical indications. Lipoproteins are risk factors for cardiovascular disease. Recent advances include the identification of factors in the synthesis and secretion of triglyceride rich lipoproteins, chylomicrons (CM) and very low density lipoproteins (VLDL). These included the identification of microsomal transfer protein, the cotranslational targeting of apoproteinB (apoB) for degradation regulated by the availability of lipids, and the characterization of transport vesicles transporting primordial apoB containing particles to the Golgi. The lipase maturation factor 1, glycosylphosphatidylinositol-anchored high density lipoprotein binding protein 1 and an angiopoietin-like protein play a role in lipoprotein lipase (LPL)-mediated hydrolysis of secreted CMs and VLDL so that the right amount of fatty acid is delivered to the right tissue at the right time. Expression of the low density lipoprotein (LDL) receptor is regulated at both transcriptional and post-transcriptional level. Proprotein convertase subtilisin/kexin type 9 (PCSK9) has a pivotal role in the degradation of LDL receptor. Plasma remnant lipoproteins bind to specific receptors in the liver, the LDL receptor, VLDL receptor and LDL receptor-like proteins prior to removal from the plasma. Reverse cholesterol transport occurs when lipid free apoAI recruits cholesterol and phospholipid to assemble high density lipoprotein (HDL) particles. The discovery of ABC transporters (ABCA1 and ABCG1) and scavenger receptor class B type I (SR-BI) provided further information on the biogenesis of HDL. In humans HDL-cholesterol can be returned to the liver either by direct uptake by SR-BI or through cholesteryl ester transfer protein exchange of cholesteryl ester for triglycerides in apoB lipoproteins, followed by hepatic uptake of apoB containing particles. Cholesterol content in cells is regulated by several transcription factors, including the liver X receptor and sterol regulatory element binding protein. This review summarizes recent advances in knowledge of the molecular mechanisms regulating lipoprotein metabolism." @default.
• W1994501461 created "2016-06-24" @default.
• W1994501461 creator A5037308009 @default.
• W1994501461 date "2014-01-01" @default.
• W1994501461 modified "2023-10-13" @default.
• W1994501461 title "Recent advances in physiological lipoprotein metabolism" @default.
• W1994501461 cites W1489280123 @default.
• W1994501461 cites W149694075 @default.
• W1994501461 cites W1524478189 @default.
• W1994501461 cites W1566044237 @default.
• W1994501461 cites W1966124841 @default.
• W1994501461 cites W1966190991 @default.
• W1994501461 cites W1969349787 @default.
• W1994501461 cites W1973856139 @default.
• W1994501461 cites W1975168532 @default.
• W1994501461 cites W1979390074 @default.
• W1994501461 cites W1980841853 @default.
• W1994501461 cites W1991328311 @default.
• W1994501461 cites W2002146594 @default.
• W1994501461 cites W2002329577 @default.
• W1994501461 cites W2014146744 @default.
• W1994501461 cites W2014882699 @default.
• W1994501461 cites W2017113887 @default.
• W1994501461 cites W2019050982 @default.
• W1994501461 cites W2020237364 @default.
• W1994501461 cites W2028858008 @default.
• W1994501461 cites W2029636772 @default.
• W1994501461 cites W2039988386 @default.
• W1994501461 cites W2040612932 @default.
• W1994501461 cites W2045878565 @default.
• W1994501461 cites W2045974381 @default.
• W1994501461 cites W2048978769 @default.
• W1994501461 cites W2052987579 @default.
• W1994501461 cites W2056761658 @default.
• W1994501461 cites W2060008696 @default.
• W1994501461 cites W2064366700 @default.
• W1994501461 cites W2070752858 @default.
• W1994501461 cites W2075027229 @default.
• W1994501461 cites W2081860696 @default.
• W1994501461 cites W2087844429 @default.
• W1994501461 cites W2088859305 @default.
• W1994501461 cites W2094477599 @default.
• W1994501461 cites W2098145494 @default.
• W1994501461 cites W2098890974 @default.
• W1994501461 cites W2100689343 @default.
• W1994501461 cites W2102161788 @default.
• W1994501461 cites W2104603759 @default.
• W1994501461 cites W2107940734 @default.
• W1994501461 cites W2108018713 @default.
• W1994501461 cites W2109320834 @default.
• W1994501461 cites W2110543371 @default.
• W1994501461 cites W2111570219 @default.
• W1994501461 cites W2114081556 @default.
• W1994501461 cites W2114199907 @default.
• W1994501461 cites W2116141123 @default.
• W1994501461 cites W2121244624 @default.
• W1994501461 cites W2123715983 @default.
• W1994501461 cites W2124187137 @default.
• W1994501461 cites W2125782351 @default.
• W1994501461 cites W2128616258 @default.
• W1994501461 cites W2130336990 @default.
• W1994501461 cites W2130530752 @default.
• W1994501461 cites W2131586382 @default.
• W1994501461 cites W2131640741 @default.
• W1994501461 cites W2135532774 @default.
• W1994501461 cites W2137827836 @default.
• W1994501461 cites W2139143846 @default.
• W1994501461 cites W2141731387 @default.
• W1994501461 cites W2142263097 @default.
• W1994501461 cites W2145532583 @default.
• W1994501461 cites W2145642828 @default.
• W1994501461 cites W2151276108 @default.
• W1994501461 cites W2151400756 @default.
• W1994501461 cites W2151675684 @default.
• W1994501461 cites W2158721108 @default.
• W1994501461 cites W2159054534 @default.
• W1994501461 cites W2159504081 @default.
• W1994501461 cites W2159995160 @default.
• W1994501461 cites W2161013959 @default.
• W1994501461 cites W2162992895 @default.
• W1994501461 cites W2163488353 @default.
• W1994501461 cites W2170183132 @default.
• W1994501461 cites W2170549593 @default.
• W1994501461 cites W2171474087 @default.
• W1994501461 cites W2171779663 @default.
• W1994501461 cites W2325083664 @default.
• W1994501461 cites W2334791394 @default.
• W1994501461 cites W2347061855 @default.
• W1994501461 doi "https://doi.org/10.1515/cclm-2013-0358" @default.
• W1994501461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23940067" @default.
• W1994501461 hasPublicationYear "2014" @default.
• W1994501461 type Work @default.
• W1994501461 sameAs 1994501461 @default.
• W1994501461 citedByCount "149" @default.
• W1994501461 countsByYear W19945014612013 @default.
• W1994501461 countsByYear W19945014612014 @default.
• W1994501461 countsByYear W19945014612015 @default.
• W1994501461 countsByYear W19945014612016 @default.
• W1994501461 countsByYear W19945014612017 @default.
• W1994501461 countsByYear W19945014612018 @default.

• next