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- W1994502118 abstract "(±)-15-Deoxyspergualin (DSG) has recently been marketed in Japan for the control of corticoresistant acute renal graft rejection. A nine-step total synthesis of its eutomer ((−)-DSG) 2 has been developed starting from 7-bromoheptanenitrile 3 and N1,N4-bis(benzyloxycarbonyl)spermidine. The use of a chiral α-alkylbenzyl group to protect the hydroxyl of the α-hydroxyglycine moiety allowed its chromatographic resolution and afforded a practical access to 2 with a high optical purity and a 7% overall yield. Moreover, X-ray structure analysis of the key crystalline intermediate 7b definitely confirmed the previously proposed absolute configuration of 2." @default.
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- W1994502118 date "2010-06-15" @default.
- W1994502118 modified "2023-09-25" @default.
- W1994502118 title "ChemInform Abstract: (-)-15-Deoxyspergualin: A New and Efficient Enantioselective Synthesis Which Allows the Definitive Assignment of the Absolute Configuration." @default.
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- W1994502118 doi "https://doi.org/10.1002/chin.199922214" @default.
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