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• W1994502400 startingPage "2847" @default.
• W1994502400 abstract "Y-family DNA polymerases have spacious active sites that can accommodate a wide variety of geometric distortions. As a consequence, they are considerably more error-prone than high-fidelity replicases. It is hardly surprising, therefore, that the in vivo activity of these polymerases is tightly regulated, so as to minimize their inadvertent access to primer-termini. We report here that one such mechanism employed by human cells relies on a specific and direct interaction between DNA polymerases iota and eta with ubiquitin (Ub). Indeed, we show that both polymerases interact noncovalently with free polyUb chains, as well as mono-ubiquitinated proliferating cell nuclear antigen (Ub-PCNA). Mutants of poliota (P692R) and poleta (H654A) were isolated that are defective in their interactions with polyUb and Ub-PCNA, whilst retaining their ability to interact with unmodified PCNA. Interestingly, the polymerase mutants exhibit significantly lower levels of replication foci in response to DNA damage, thereby highlighting the biological importance of the polymerase-Ub interaction in regulating the access of the TLS polymerases to stalled replication forks in vivo." @default.
• W1994502400 created "2016-06-24" @default.
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• W1994502400 date "2006-06-08" @default.
• W1994502400 modified "2023-10-16" @default.
• W1994502400 title "Controlling the subcellular localization of DNA polymerases ι and η via interactions with ubiquitin" @default.
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• W1994502400 doi "https://doi.org/10.1038/sj.emboj.7601178" @default.
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