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- W1994505402 abstract "Thirty-five adult patients with rheumatoid arthritis received for 36 interscalene brachial plexus blocks a standard dose of bupivacaine 200 mg, regardless of the weight (range 39.2-102.5 kg) of the patient. The peak venous serum concentrations (Cmax) of bupivacaine, measured by HPLC, were in the range 0.82-4.30 mg litre-1; there were no signs of toxicity. There was a very significant inverse correlation between the Cmax of bupivacaine and the weight of the patient (r = -0.5922; t = -4.285; P = 0.0001, Pearson's test). In spite of the correlation, only 35.1% of the total variance could be explained by regression. Thus weight had little influence on Cmax under interscalene brachial plexus block." @default.
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- W1994505402 date "1991-11-01" @default.
- W1994505402 modified "2023-09-28" @default.
- W1994505402 title "INVERSE CORRELATION BETWEEN THE PEAK VENOUS SERUM CONCENTRATION OF BUPIVACAINE AND THE WEIGHT OF THE PATIENT DURING INTERSCALENE BRACHIAL PLEXUS BLOCK" @default.
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- W1994505402 doi "https://doi.org/10.1093/bja/67.5.621" @default.
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