FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994508726> ?p ?o ?g. }

• W1994508726 endingPage "378" @default.
• W1994508726 startingPage "370" @default.
• W1994508726 abstract "Understanding the dynamics of the actin filament is essential to a detailed description of their interactions and role in the cell. Previous studies have linked the dynamic properties of actin filaments (F-actin) to three structural elements contributing to a hydrophobic pocket, namely, the hydrophobic loop, the DNase I binding loop, and the C-terminus. Here, we examine how these structural elements are influenced by factors that stabilize or destabilize F-actin, using site-directed spin-labeled (SDSL) electron paramagnetic resonance (EPR), fluorescence, and cross-linking techniques. Specifically, we employ cofilin, an actin destabilizing protein that binds and severs filaments, and phalloidin, a fungal toxin that binds and stabilizes F-actin. We find that cofilin shifts both the DNase I binding loop and the hydrophobic loop away from the C-terminus in F-actin, as demonstrated by weakened spin-spin interactions, and alters the environment of spin probes on residues of these two loops. In contrast, although phalloidin strongly stabilizes F-actin, it causes little or no local change in the environment of the loop residues. This indicates that the stabilizing effect of phalloidin is achieved mainly through constraining structural fluctuations in F-actin and suggests that factors and interactions that control these fluctuations have an important role in the cytoskeleton dynamics." @default.
• W1994508726 created "2016-06-24" @default.
• W1994508726 creator A5007619343 @default.
• W1994508726 creator A5026526352 @default.
• W1994508726 creator A5036133609 @default.
• W1994508726 creator A5038398169 @default.
• W1994508726 creator A5052984331 @default.
• W1994508726 creator A5054619686 @default.
• W1994508726 creator A5084919959 @default.
• W1994508726 creator A5086589671 @default.
• W1994508726 date "2008-12-29" @default.
• W1994508726 modified "2023-09-26" @default.
• W1994508726 title "Effects of Binding Factors on Structural Elements in F-Actin" @default.
• W1994508726 cites W1489872162 @default.
• W1994508726 cites W1970072446 @default.
• W1994508726 cites W1972838089 @default.
• W1994508726 cites W1974329525 @default.
• W1994508726 cites W1975934167 @default.
• W1994508726 cites W1978092836 @default.
• W1994508726 cites W1984559046 @default.
• W1994508726 cites W1985210076 @default.
• W1994508726 cites W1985221295 @default.
• W1994508726 cites W2010418330 @default.
• W1994508726 cites W2015730491 @default.
• W1994508726 cites W2016948812 @default.
• W1994508726 cites W2025346903 @default.
• W1994508726 cites W2026064166 @default.
• W1994508726 cites W2027539640 @default.
• W1994508726 cites W2032049213 @default.
• W1994508726 cites W2032290739 @default.
• W1994508726 cites W2033349399 @default.
• W1994508726 cites W2039127734 @default.
• W1994508726 cites W2043664506 @default.
• W1994508726 cites W2045621376 @default.
• W1994508726 cites W2046314964 @default.
• W1994508726 cites W2051519450 @default.
• W1994508726 cites W2051804031 @default.
• W1994508726 cites W2057872900 @default.
• W1994508726 cites W2062704019 @default.
• W1994508726 cites W2067106661 @default.
• W1994508726 cites W2070967303 @default.
• W1994508726 cites W2087391064 @default.
• W1994508726 cites W2105082854 @default.
• W1994508726 cites W2122812094 @default.
• W1994508726 cites W2125927252 @default.
• W1994508726 cites W2126546276 @default.
• W1994508726 cites W2127621643 @default.
• W1994508726 cites W2130687290 @default.
• W1994508726 cites W2145367033 @default.
• W1994508726 cites W2147925684 @default.
• W1994508726 cites W4256249882 @default.
• W1994508726 doi "https://doi.org/10.1021/bi801649j" @default.
• W1994508726 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3133778" @default.
• W1994508726 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19113841" @default.
• W1994508726 hasPublicationYear "2008" @default.
• W1994508726 type Work @default.
• W1994508726 sameAs 1994508726 @default.
• W1994508726 citedByCount "16" @default.
• W1994508726 countsByYear W19945087262013 @default.
• W1994508726 countsByYear W19945087262014 @default.
• W1994508726 countsByYear W19945087262015 @default.
• W1994508726 countsByYear W19945087262016 @default.
• W1994508726 countsByYear W19945087262017 @default.
• W1994508726 countsByYear W19945087262020 @default.
• W1994508726 countsByYear W19945087262021 @default.
• W1994508726 crossrefType "journal-article" @default.
• W1994508726 hasAuthorship W1994508726A5007619343 @default.
• W1994508726 hasAuthorship W1994508726A5026526352 @default.
• W1994508726 hasAuthorship W1994508726A5036133609 @default.
• W1994508726 hasAuthorship W1994508726A5038398169 @default.
• W1994508726 hasAuthorship W1994508726A5052984331 @default.
• W1994508726 hasAuthorship W1994508726A5054619686 @default.
• W1994508726 hasAuthorship W1994508726A5084919959 @default.
• W1994508726 hasAuthorship W1994508726A5086589671 @default.
• W1994508726 hasBestOaLocation W19945087262 @default.
• W1994508726 hasConcept C12554922 @default.
• W1994508726 hasConcept C125705527 @default.
• W1994508726 hasConcept C14228908 @default.
• W1994508726 hasConcept C142669718 @default.
• W1994508726 hasConcept C1491633281 @default.
• W1994508726 hasConcept C185592680 @default.
• W1994508726 hasConcept C2776601116 @default.
• W1994508726 hasConcept C2776861759 @default.
• W1994508726 hasConcept C2993400109 @default.
• W1994508726 hasConcept C3620293 @default.
• W1994508726 hasConcept C55493867 @default.
• W1994508726 hasConcept C8010536 @default.
• W1994508726 hasConcept C86803240 @default.
• W1994508726 hasConceptScore W1994508726C12554922 @default.
• W1994508726 hasConceptScore W1994508726C125705527 @default.
• W1994508726 hasConceptScore W1994508726C14228908 @default.
• W1994508726 hasConceptScore W1994508726C142669718 @default.
• W1994508726 hasConceptScore W1994508726C1491633281 @default.
• W1994508726 hasConceptScore W1994508726C185592680 @default.
• W1994508726 hasConceptScore W1994508726C2776601116 @default.
• W1994508726 hasConceptScore W1994508726C2776861759 @default.
• W1994508726 hasConceptScore W1994508726C2993400109 @default.
• W1994508726 hasConceptScore W1994508726C3620293 @default.

• next