FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994516214> ?p ?o ?g. }

• W1994516214 endingPage "95" @default.
• W1994516214 startingPage "89" @default.
• W1994516214 abstract "BackgroundHigh mobility group box1 (HMGB1) and poly(ADP-ribose) polymerase1 (PARP1) proteins repair cellular DNA damage. Reduced expression of the corresponding genes can lead to an impaired DNA damage repair mechanism. Intracellular replication of hepatitis B virus (HBV) in such conditions can favor the integration of viral DNA into host genome leading to the development of hepatocellular carcinoma (HCC).ObjectiveThis study was performed to assess the expression of HMGB1 and PARP1 mRNAs in conjunction with the estimation of HBV replication intermediate pregenomic RNA (PgRNA) in various phases of HBV infection.MaterialsEighty eight patients and 26 voluntary blood donors as controls were included in the study. Patients were grouped in to acute (AHB; n = 15), inactive carriers (IC; n = 36), cirrhosis (Cirr; n = 25) and hepatocellular carcinoma (HCC; n = 12). Serum HBV DNA was quantified by real time polymerase chain reaction (PCR) assay. Expression of HMGB1, PARP1 and PgRNA were evaluated using peripheral blood mononuclear cells (PBMCs) derived RNA by reverse transcription PCR (RT-PCR) and densitometry.ResultsSignificant reduction of HMGB1 and PARP1 gene expressions (P < 0.05) were observed in patients than controls with more explicit decline of PARP1 (P = 0.0002). Both genes were significantly downregulated (P < 0.001) in ICs than controls. In ICs, HMGB1 was significantly lowered than cirrhosis (P = 0.002) and HCC (P = 0.0006) while PARP1 declined significantly (P = 0.04) than HCC. Level of PgRNA was comparable in all the disease categories.ConclusionIn conclusion, our findings indicate impaired DNA damage repair mechanisms in HBV infected cells of ICs. This, along with low viral load but higher level of PgRNA in this group is suggestive of the diversion of HBV replication pathway that might facilitate viral DNA integration in to host genome. Intrusion of HBV PgRNA reverse transcription in early stage of infection might appear advantageous to thwart the development of HCC. High mobility group box1 (HMGB1) and poly(ADP-ribose) polymerase1 (PARP1) proteins repair cellular DNA damage. Reduced expression of the corresponding genes can lead to an impaired DNA damage repair mechanism. Intracellular replication of hepatitis B virus (HBV) in such conditions can favor the integration of viral DNA into host genome leading to the development of hepatocellular carcinoma (HCC). This study was performed to assess the expression of HMGB1 and PARP1 mRNAs in conjunction with the estimation of HBV replication intermediate pregenomic RNA (PgRNA) in various phases of HBV infection. Eighty eight patients and 26 voluntary blood donors as controls were included in the study. Patients were grouped in to acute (AHB; n = 15), inactive carriers (IC; n = 36), cirrhosis (Cirr; n = 25) and hepatocellular carcinoma (HCC; n = 12). Serum HBV DNA was quantified by real time polymerase chain reaction (PCR) assay. Expression of HMGB1, PARP1 and PgRNA were evaluated using peripheral blood mononuclear cells (PBMCs) derived RNA by reverse transcription PCR (RT-PCR) and densitometry. Significant reduction of HMGB1 and PARP1 gene expressions (P < 0.05) were observed in patients than controls with more explicit decline of PARP1 (P = 0.0002). Both genes were significantly downregulated (P < 0.001) in ICs than controls. In ICs, HMGB1 was significantly lowered than cirrhosis (P = 0.002) and HCC (P = 0.0006) while PARP1 declined significantly (P = 0.04) than HCC. Level of PgRNA was comparable in all the disease categories. In conclusion, our findings indicate impaired DNA damage repair mechanisms in HBV infected cells of ICs. This, along with low viral load but higher level of PgRNA in this group is suggestive of the diversion of HBV replication pathway that might facilitate viral DNA integration in to host genome. Intrusion of HBV PgRNA reverse transcription in early stage of infection might appear advantageous to thwart the development of HCC." @default.
• W1994516214 created "2016-06-24" @default.
• W1994516214 creator A5009988648 @default.
• W1994516214 creator A5021910135 @default.
• W1994516214 creator A5029455812 @default.
• W1994516214 creator A5052683471 @default.
• W1994516214 creator A5062210742 @default.
• W1994516214 creator A5065577394 @default.
• W1994516214 creator A5073670795 @default.
• W1994516214 creator A5081493552 @default.
• W1994516214 creator A5090934923 @default.
• W1994516214 date "2013-06-01" @default.
• W1994516214 modified "2023-10-06" @default.
• W1994516214 title "Reduced Expression of DNA Damage Repair Genes High Mobility Group Box1 and Poly(ADP-ribose) Polymerase1 in Inactive Carriers of Hepatitis B Virus Infection-A Possible Stage of Viral Integration" @default.
• W1994516214 cites W1506913645 @default.
• W1994516214 cites W1972443740 @default.
• W1994516214 cites W1974970634 @default.
• W1994516214 cites W1980927876 @default.
• W1994516214 cites W1992476369 @default.
• W1994516214 cites W1999337265 @default.
• W1994516214 cites W1999991146 @default.
• W1994516214 cites W2006011870 @default.
• W1994516214 cites W2010144425 @default.
• W1994516214 cites W2012619167 @default.
• W1994516214 cites W2015763479 @default.
• W1994516214 cites W2020813760 @default.
• W1994516214 cites W2022111057 @default.
• W1994516214 cites W2031317669 @default.
• W1994516214 cites W2040799770 @default.
• W1994516214 cites W2055071452 @default.
• W1994516214 cites W2074118280 @default.
• W1994516214 cites W2075595885 @default.
• W1994516214 cites W2077311317 @default.
• W1994516214 cites W2095665485 @default.
• W1994516214 cites W2107057287 @default.
• W1994516214 cites W2116929627 @default.
• W1994516214 cites W2120650696 @default.
• W1994516214 cites W2124535107 @default.
• W1994516214 cites W2135991340 @default.
• W1994516214 cites W2142623408 @default.
• W1994516214 cites W2143056112 @default.
• W1994516214 cites W2147426561 @default.
• W1994516214 cites W2148661005 @default.
• W1994516214 cites W2149928705 @default.
• W1994516214 cites W2156015715 @default.
• W1994516214 cites W2157031657 @default.
• W1994516214 cites W2163486683 @default.
• W1994516214 cites W2166826446 @default.
• W1994516214 cites W2397954892 @default.
• W1994516214 cites W2591717879 @default.
• W1994516214 cites W4231124841 @default.
• W1994516214 doi "https://doi.org/10.1016/j.jceh.2013.04.003" @default.
• W1994516214 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3940113" @default.
• W1994516214 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25755481" @default.
• W1994516214 hasPublicationYear "2013" @default.
• W1994516214 type Work @default.
• W1994516214 sameAs 1994516214 @default.
• W1994516214 citedByCount "11" @default.
• W1994516214 countsByYear W19945162142014 @default.
• W1994516214 countsByYear W19945162142017 @default.
• W1994516214 countsByYear W19945162142019 @default.
• W1994516214 countsByYear W19945162142020 @default.
• W1994516214 countsByYear W19945162142021 @default.
• W1994516214 countsByYear W19945162142022 @default.
• W1994516214 crossrefType "journal-article" @default.
• W1994516214 hasAuthorship W1994516214A5009988648 @default.
• W1994516214 hasAuthorship W1994516214A5021910135 @default.
• W1994516214 hasAuthorship W1994516214A5029455812 @default.
• W1994516214 hasAuthorship W1994516214A5052683471 @default.
• W1994516214 hasAuthorship W1994516214A5062210742 @default.
• W1994516214 hasAuthorship W1994516214A5065577394 @default.
• W1994516214 hasAuthorship W1994516214A5073670795 @default.
• W1994516214 hasAuthorship W1994516214A5081493552 @default.
• W1994516214 hasAuthorship W1994516214A5090934923 @default.
• W1994516214 hasBestOaLocation W19945162141 @default.
• W1994516214 hasConcept C104317684 @default.
• W1994516214 hasConcept C126322002 @default.
• W1994516214 hasConcept C134935766 @default.
• W1994516214 hasConcept C135763542 @default.
• W1994516214 hasConcept C137061746 @default.
• W1994516214 hasConcept C143425029 @default.
• W1994516214 hasConcept C153209595 @default.
• W1994516214 hasConcept C153911025 @default.
• W1994516214 hasConcept C159047783 @default.
• W1994516214 hasConcept C182979987 @default.
• W1994516214 hasConcept C202751555 @default.
• W1994516214 hasConcept C203014093 @default.
• W1994516214 hasConcept C2522874641 @default.
• W1994516214 hasConcept C2776408679 @default.
• W1994516214 hasConcept C2776914184 @default.
• W1994516214 hasConcept C2776999993 @default.
• W1994516214 hasConcept C2777214474 @default.
• W1994516214 hasConcept C2778019345 @default.
• W1994516214 hasConcept C2778480876 @default.
• W1994516214 hasConcept C2780545709 @default.
• W1994516214 hasConcept C2780593183 @default.
• W1994516214 hasConcept C48023723 @default.
• W1994516214 hasConcept C502942594 @default.

• next