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- W1994517931 abstract "In recent years, quantitative studies of the neuropathology of schizophrenia have reignited interest in the cerebral cortex and focused attention on the cellular and subcellular constituents that may be altered in this disease. Findings have ranged from compromised circuitry in prefrontal areas to outright neuronal loss in temporal and cingulate cortices. Herein, we propose that a reduction in interneuronal neuropil in the prefrontal cortex is a prominent feature of cortical pathology in schizophrenia and review the growing evidence for this view from reports of altered neuronal density and immunohistochemical markers in various cortical regions. The emerging picture of neuropathology in schizophrenia is one of subtle changes in cellular architecture and brain circuity that nonetheless have a devastating impact on cortical function." @default.
- W1994517931 created "2016-06-24" @default.
- W1994517931 creator A5017501933 @default.
- W1994517931 creator A5086254455 @default.
- W1994517931 date "1999-01-01" @default.
- W1994517931 modified "2023-10-04" @default.
- W1994517931 title "The reduced neuropil hypothesis: a circuit based model of schizophrenia" @default.
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- W1994517931 doi "https://doi.org/10.1016/s0006-3223(98)00281-9" @default.
- W1994517931 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9894571" @default.
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