Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994528815> ?p ?o ?g. }
- W1994528815 endingPage "26" @default.
- W1994528815 startingPage "17" @default.
- W1994528815 abstract "The purpose of this study was to investigate the effect of combination of LBH589 with docetaxel (DTX) on the growth and survival of epithelial ovarian cancer (EOC) cells in vitro and the possible mechanisms of chemo-sensitization of LBH589 in the combination treatment. The effect of LBH589 alone or in combination with DTX on four EOC cell lines (OVCAR-3, IGROV-1, A2780 and SKOV-3) was studied by MTT and clonogenic assays, acridine orange (AO)/ethidium bromide (EB) staining for apoptosis, Western blotting for apoptosis-related proteins, histone H3 and H4 proteins, DNA double strand break (DSB) repair marker and phosphorylation of Akt. LBH589 alone inhibited EOC cell proliferation in a time and dose-dependent manner. Low-dose of LBH589 (IC(20)) combined with DTX had an additive effect and greatly improved efficacy of DTX cell killing in EOC cells. Compared to DTX alone, the combination treatment with LBH589 and DTX induced more apoptosis and led to an increased and persistent DSB. Cell death following single or combined treatment was associated with the release of cytochrome c activity, increased caspase-3 (active) and PARP-1(cleaved), histone acetylation-related proteins and PI3k/Akt signaling pathway. Our results suggest that LBH589 enhances DTX-induced apoptosis in human EOC cells, and can be used in combination with DTX as an attractive strategy for treating human EOC." @default.
- W1994528815 created "2016-06-24" @default.
- W1994528815 creator A5000417932 @default.
- W1994528815 creator A5012278873 @default.
- W1994528815 creator A5023214008 @default.
- W1994528815 creator A5033315995 @default.
- W1994528815 creator A5051081748 @default.
- W1994528815 creator A5066623745 @default.
- W1994528815 creator A5077746503 @default.
- W1994528815 creator A5086916480 @default.
- W1994528815 date "2013-02-01" @default.
- W1994528815 modified "2023-09-22" @default.
- W1994528815 title "Low dose histone deacetylase inhibitor, LBH589, potentiates anticancer effect of docetaxel in epithelial ovarian cancer via PI3K/Akt pathway in vitro" @default.
- W1994528815 cites W1591187753 @default.
- W1994528815 cites W1963861821 @default.
- W1994528815 cites W1965986986 @default.
- W1994528815 cites W1967018540 @default.
- W1994528815 cites W1968785826 @default.
- W1994528815 cites W1972027082 @default.
- W1994528815 cites W1973666076 @default.
- W1994528815 cites W1982619775 @default.
- W1994528815 cites W1992476369 @default.
- W1994528815 cites W1996180957 @default.
- W1994528815 cites W1999224816 @default.
- W1994528815 cites W2013105209 @default.
- W1994528815 cites W2019572526 @default.
- W1994528815 cites W2021395683 @default.
- W1994528815 cites W2021516227 @default.
- W1994528815 cites W2023237279 @default.
- W1994528815 cites W2023939814 @default.
- W1994528815 cites W2029962300 @default.
- W1994528815 cites W2031469256 @default.
- W1994528815 cites W2034020928 @default.
- W1994528815 cites W2034985442 @default.
- W1994528815 cites W2040330598 @default.
- W1994528815 cites W2045401698 @default.
- W1994528815 cites W2050089788 @default.
- W1994528815 cites W2055632192 @default.
- W1994528815 cites W2066264051 @default.
- W1994528815 cites W2069116711 @default.
- W1994528815 cites W2073221931 @default.
- W1994528815 cites W2080726143 @default.
- W1994528815 cites W2081145901 @default.
- W1994528815 cites W2087408588 @default.
- W1994528815 cites W2088231330 @default.
- W1994528815 cites W2090284404 @default.
- W1994528815 cites W2093003148 @default.
- W1994528815 cites W2096906921 @default.
- W1994528815 cites W2099030380 @default.
- W1994528815 cites W2099803844 @default.
- W1994528815 cites W2114468318 @default.
- W1994528815 cites W2132880072 @default.
- W1994528815 cites W2150642119 @default.
- W1994528815 cites W2157595683 @default.
- W1994528815 cites W2158364619 @default.
- W1994528815 cites W2158734599 @default.
- W1994528815 doi "https://doi.org/10.1016/j.canlet.2012.08.035" @default.
- W1994528815 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22995071" @default.
- W1994528815 hasPublicationYear "2013" @default.
- W1994528815 type Work @default.
- W1994528815 sameAs 1994528815 @default.
- W1994528815 citedByCount "24" @default.
- W1994528815 countsByYear W19945288152013 @default.
- W1994528815 countsByYear W19945288152014 @default.
- W1994528815 countsByYear W19945288152015 @default.
- W1994528815 countsByYear W19945288152016 @default.
- W1994528815 countsByYear W19945288152017 @default.
- W1994528815 countsByYear W19945288152018 @default.
- W1994528815 countsByYear W19945288152019 @default.
- W1994528815 countsByYear W19945288152021 @default.
- W1994528815 countsByYear W19945288152022 @default.
- W1994528815 crossrefType "journal-article" @default.
- W1994528815 hasAuthorship W1994528815A5000417932 @default.
- W1994528815 hasAuthorship W1994528815A5012278873 @default.
- W1994528815 hasAuthorship W1994528815A5023214008 @default.
- W1994528815 hasAuthorship W1994528815A5033315995 @default.
- W1994528815 hasAuthorship W1994528815A5051081748 @default.
- W1994528815 hasAuthorship W1994528815A5066623745 @default.
- W1994528815 hasAuthorship W1994528815A5077746503 @default.
- W1994528815 hasAuthorship W1994528815A5086916480 @default.
- W1994528815 hasConcept C117262875 @default.
- W1994528815 hasConcept C153911025 @default.
- W1994528815 hasConcept C182979987 @default.
- W1994528815 hasConcept C190283241 @default.
- W1994528815 hasConcept C2776202225 @default.
- W1994528815 hasConcept C2778305200 @default.
- W1994528815 hasConcept C2780225316 @default.
- W1994528815 hasConcept C31573885 @default.
- W1994528815 hasConcept C502942594 @default.
- W1994528815 hasConcept C552990157 @default.
- W1994528815 hasConcept C55493867 @default.
- W1994528815 hasConcept C64927066 @default.
- W1994528815 hasConcept C75217442 @default.
- W1994528815 hasConcept C82381507 @default.
- W1994528815 hasConcept C86554907 @default.
- W1994528815 hasConcept C86803240 @default.
- W1994528815 hasConceptScore W1994528815C117262875 @default.
- W1994528815 hasConceptScore W1994528815C153911025 @default.