FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994531379> ?p ?o ?g. }

• W1994531379 endingPage "145" @default.
• W1994531379 startingPage "136" @default.
• W1994531379 abstract "The early stages of type 2 diabetes mellitus are characterized by the development of insulin resistance (IRe) in muscle cells and adipocytes with the concomitant loss of beta-cell compensation. We have extensively reviewed the literature related to metabolic and signalling pathways of reactive oxygen species (ROS) in regard to the coordinated development of oxidative stress and IRe. We considered the hypothesis that oxidative stress leads to IRe in muscle cells and adipocytes, but found that the data are more consistent with the hypothesis that the cellular mechanisms that protect against oxidative stress per se are capable of creating an ROS-dependent insulin-resistant state. Furthermore, ROS-induced mitochondrial dysfunction can lead to disruptions of lipid metabolism, increasing the intracellular lipid content, and, in addition, contribute to lipid-dependent IRe in myocytes. Together, these two ROS-activated pathways to IRe can contribute to a global state of profound resistance to insulin action. Therapeutic strategies should, therefore, be directed towards reducing insulin resistance without an increase in ROS production or concentration. Pharmacological or other approaches to IRe that result in the activation of mitochondrial biogenesis in particular could be highly beneficial in the prevention or treatment of both insulin resistance and type 2 diabetes." @default.
• W1994531379 created "2016-06-24" @default.
• W1994531379 creator A5045927870 @default.
• W1994531379 creator A5073002116 @default.
• W1994531379 date "2005-04-25" @default.
• W1994531379 modified "2023-10-10" @default.
• W1994531379 title "Reactive species and early manifestation of insulin resistance in type 2 diabetes" @default.
• W1994531379 cites W1272300955 @default.
• W1994531379 cites W1529592271 @default.
• W1994531379 cites W1734082729 @default.
• W1994531379 cites W1849928642 @default.
• W1994531379 cites W1876476959 @default.
• W1994531379 cites W1968010896 @default.
• W1994531379 cites W1972011552 @default.
• W1994531379 cites W1975268482 @default.
• W1994531379 cites W1976422365 @default.
• W1994531379 cites W1997065838 @default.
• W1994531379 cites W1998091582 @default.
• W1994531379 cites W1998227193 @default.
• W1994531379 cites W2000511325 @default.
• W1994531379 cites W2012898950 @default.
• W1994531379 cites W2014901805 @default.
• W1994531379 cites W2022627623 @default.
• W1994531379 cites W2027670788 @default.
• W1994531379 cites W2031637294 @default.
• W1994531379 cites W2035836674 @default.
• W1994531379 cites W2047263793 @default.
• W1994531379 cites W2050277889 @default.
• W1994531379 cites W2050897300 @default.
• W1994531379 cites W2059467226 @default.
• W1994531379 cites W2065789432 @default.
• W1994531379 cites W2067184340 @default.
• W1994531379 cites W2072959501 @default.
• W1994531379 cites W2072989847 @default.
• W1994531379 cites W2083990676 @default.
• W1994531379 cites W2084035076 @default.
• W1994531379 cites W2090156279 @default.
• W1994531379 cites W2091034365 @default.
• W1994531379 cites W2096057450 @default.
• W1994531379 cites W2100066777 @default.
• W1994531379 cites W2100371568 @default.
• W1994531379 cites W2104865391 @default.
• W1994531379 cites W2108462699 @default.
• W1994531379 cites W2109286159 @default.
• W1994531379 cites W2109818274 @default.
• W1994531379 cites W2110542127 @default.
• W1994531379 cites W2112858824 @default.
• W1994531379 cites W2113515610 @default.
• W1994531379 cites W2113544353 @default.
• W1994531379 cites W2113754802 @default.
• W1994531379 cites W2114978842 @default.
• W1994531379 cites W2116379387 @default.
• W1994531379 cites W2120563796 @default.
• W1994531379 cites W2121491699 @default.
• W1994531379 cites W2123766698 @default.
• W1994531379 cites W2127985487 @default.
• W1994531379 cites W2130850001 @default.
• W1994531379 cites W2132557269 @default.
• W1994531379 cites W2133516203 @default.
• W1994531379 cites W2141429873 @default.
• W1994531379 cites W2145261918 @default.
• W1994531379 cites W2145333208 @default.
• W1994531379 cites W2154682611 @default.
• W1994531379 cites W2154768987 @default.
• W1994531379 cites W2155227094 @default.
• W1994531379 cites W2158254429 @default.
• W1994531379 cites W2158449289 @default.
• W1994531379 cites W2158563216 @default.
• W1994531379 cites W2159622967 @default.
• W1994531379 cites W2170651583 @default.
• W1994531379 cites W2328294727 @default.
• W1994531379 cites W2430143578 @default.
• W1994531379 cites W4230991698 @default.
• W1994531379 cites W4243290059 @default.
• W1994531379 cites W4293097131 @default.
• W1994531379 cites W4293255174 @default.
• W1994531379 doi "https://doi.org/10.1111/j.1463-1326.2005.00496.x" @default.
• W1994531379 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16448517" @default.
• W1994531379 hasPublicationYear "2005" @default.
• W1994531379 type Work @default.
• W1994531379 sameAs 1994531379 @default.
• W1994531379 citedByCount "150" @default.
• W1994531379 countsByYear W19945313792012 @default.
• W1994531379 countsByYear W19945313792013 @default.
• W1994531379 countsByYear W19945313792014 @default.
• W1994531379 countsByYear W19945313792015 @default.
• W1994531379 countsByYear W19945313792016 @default.
• W1994531379 countsByYear W19945313792017 @default.
• W1994531379 countsByYear W19945313792018 @default.
• W1994531379 countsByYear W19945313792019 @default.
• W1994531379 countsByYear W19945313792020 @default.
• W1994531379 countsByYear W19945313792021 @default.
• W1994531379 countsByYear W19945313792022 @default.
• W1994531379 countsByYear W19945313792023 @default.
• W1994531379 crossrefType "journal-article" @default.
• W1994531379 hasAuthorship W1994531379A5045927870 @default.
• W1994531379 hasAuthorship W1994531379A5073002116 @default.
• W1994531379 hasConcept C126322002 @default.

• next