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- W1994533434 endingPage "757" @default.
- W1994533434 startingPage "741" @default.
- W1994533434 abstract "Evidence is presented that cellular processes have a cyclic nature. The theory is advanced that this is controlled by a periodic charge exchange between actin and myosin, regulated by the oxidation and reduction of sulphydryl moieties. Cellular characteristics and control including mitosis are determined by the redox state of these two proteins; mitosis being determined by both the amplitude and period of the thiol cycle. It is proposed that all carcinogens, including radiation, induce an oxidation of specific myosin sulphydryl units with a concomitant reduction of specific actin sulphydryl units. They thereby initiate a thiol cycle of increased magnitude which leads to mitosis. This theory leads to predictions concerning the manner in which reducing agents should be used in the prevention and treatment of cancer." @default.
- W1994533434 created "2016-06-24" @default.
- W1994533434 creator A5053211893 @default.
- W1994533434 date "1982-06-01" @default.
- W1994533434 modified "2023-09-27" @default.
- W1994533434 title "A mitotic theory" @default.
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- W1994533434 doi "https://doi.org/10.1016/0022-5193(82)90240-5" @default.
- W1994533434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7132384" @default.
- W1994533434 hasPublicationYear "1982" @default.
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