FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994536064> ?p ?o ?g. }

• W1994536064 endingPage "445" @default.
• W1994536064 startingPage "437" @default.
• W1994536064 abstract "The SALL (Spalt-like) family of zinc-finger transcription factors is conserved in metazoans. In Drosophila Sal (Spalt) and Salr (Spalt-related) control the expression of genes involved in wing and central nervous system development, including cell adhesion and cytoskeletal proteins. In humans, SALL mutations associate with congenital disorders such as the Townes–Brocks and Okihiro syndromes. Human and Drosophila SALL proteins are modified by SUMO (small ubiquitin-related modifier), which influences their subnuclear localization. In the present study, we have analysed the transcriptional activity of Drosophila Sall proteins in cultured cells. We show that both Sal and Salr act as transcriptional repressors in Drosophila cells where they repress transcription through an AT-rich sequence. Furthermore, using the UAS/Gal4 heterologous system, Drosophila Sal and Salr repress transcription in human cells. Under our experimental conditions, only in the case of Salr is the repression activity dependent on the HDAC (histone deacetylase) complex. This complex might interact with the C-terminal zinc fingers of Salr. We describe the differential subcellular localizations of Sal and Salr fragments and identify their repression domains. Surprisingly, both repressors also contain transcription activation domains. In addition, under our experimental conditions SUMOylation has differential effects on Sal and Salr repressor activity. Phylogenetic comparison between nematodes, insects and vertebrates identifies conserved peptide sequences that are presumably critical for SALL protein function." @default.
• W1994536064 created "2016-06-24" @default.
• W1994536064 creator A5004890339 @default.
• W1994536064 creator A5006322147 @default.
• W1994536064 creator A5006502512 @default.
• W1994536064 creator A5007028831 @default.
• W1994536064 creator A5012269396 @default.
• W1994536064 creator A5013880116 @default.
• W1994536064 creator A5055330349 @default.
• W1994536064 creator A5074486047 @default.
• W1994536064 date "2011-08-26" @default.
• W1994536064 modified "2023-10-18" @default.
• W1994536064 title "<i>Drosophila</i> Sal and Salr are transcriptional repressors" @default.
• W1994536064 cites W1906734327 @default.
• W1994536064 cites W1935255769 @default.
• W1994536064 cites W1963828768 @default.
• W1994536064 cites W1968962291 @default.
• W1994536064 cites W1972796654 @default.
• W1994536064 cites W1977648882 @default.
• W1994536064 cites W1978934956 @default.
• W1994536064 cites W1979275431 @default.
• W1994536064 cites W1981138517 @default.
• W1994536064 cites W1982719386 @default.
• W1994536064 cites W1992125440 @default.
• W1994536064 cites W1994610109 @default.
• W1994536064 cites W1996395636 @default.
• W1994536064 cites W2001442967 @default.
• W1994536064 cites W2004457343 @default.
• W1994536064 cites W2009677247 @default.
• W1994536064 cites W2014700650 @default.
• W1994536064 cites W2016825447 @default.
• W1994536064 cites W2028096060 @default.
• W1994536064 cites W2029196830 @default.
• W1994536064 cites W2035633599 @default.
• W1994536064 cites W2041745051 @default.
• W1994536064 cites W2041959419 @default.
• W1994536064 cites W2045241135 @default.
• W1994536064 cites W2047954822 @default.
• W1994536064 cites W2049176937 @default.
• W1994536064 cites W2053838962 @default.
• W1994536064 cites W2053840813 @default.
• W1994536064 cites W2055852018 @default.
• W1994536064 cites W2062910407 @default.
• W1994536064 cites W2091459202 @default.
• W1994536064 cites W2096532391 @default.
• W1994536064 cites W2096753123 @default.
• W1994536064 cites W2097812689 @default.
• W1994536064 cites W2099765629 @default.
• W1994536064 cites W2109134145 @default.
• W1994536064 cites W2114302716 @default.
• W1994536064 cites W2130272450 @default.
• W1994536064 cites W2135412012 @default.
• W1994536064 cites W2138454963 @default.
• W1994536064 cites W2138768379 @default.
• W1994536064 cites W2147555186 @default.
• W1994536064 cites W2152946647 @default.
• W1994536064 cites W2163440467 @default.
• W1994536064 cites W2165157291 @default.
• W1994536064 doi "https://doi.org/10.1042/bj20110229" @default.
• W1994536064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21689070" @default.
• W1994536064 hasPublicationYear "2011" @default.
• W1994536064 type Work @default.
• W1994536064 sameAs 1994536064 @default.
• W1994536064 citedByCount "17" @default.
• W1994536064 countsByYear W19945360642012 @default.
• W1994536064 countsByYear W19945360642013 @default.
• W1994536064 countsByYear W19945360642014 @default.
• W1994536064 countsByYear W19945360642015 @default.
• W1994536064 countsByYear W19945360642017 @default.
• W1994536064 countsByYear W19945360642018 @default.
• W1994536064 countsByYear W19945360642020 @default.
• W1994536064 countsByYear W19945360642021 @default.
• W1994536064 countsByYear W19945360642023 @default.
• W1994536064 crossrefType "journal-article" @default.
• W1994536064 hasAuthorship W1994536064A5004890339 @default.
• W1994536064 hasAuthorship W1994536064A5006322147 @default.
• W1994536064 hasAuthorship W1994536064A5006502512 @default.
• W1994536064 hasAuthorship W1994536064A5007028831 @default.
• W1994536064 hasAuthorship W1994536064A5012269396 @default.
• W1994536064 hasAuthorship W1994536064A5013880116 @default.
• W1994536064 hasAuthorship W1994536064A5055330349 @default.
• W1994536064 hasAuthorship W1994536064A5074486047 @default.
• W1994536064 hasConcept C104317684 @default.
• W1994536064 hasConcept C136961756 @default.
• W1994536064 hasConcept C138885662 @default.
• W1994536064 hasConcept C150194340 @default.
• W1994536064 hasConcept C158448853 @default.
• W1994536064 hasConcept C166703698 @default.
• W1994536064 hasConcept C171350616 @default.
• W1994536064 hasConcept C179926584 @default.
• W1994536064 hasConcept C186310378 @default.
• W1994536064 hasConcept C24284526 @default.
• W1994536064 hasConcept C25602115 @default.
• W1994536064 hasConcept C2778305200 @default.
• W1994536064 hasConcept C41895202 @default.
• W1994536064 hasConcept C54355233 @default.
• W1994536064 hasConcept C64927066 @default.
• W1994536064 hasConcept C67705224 @default.

• next