FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994554141> ?p ?o ?g. }

• W1994554141 endingPage "2937" @default.
• W1994554141 startingPage "2927" @default.
• W1994554141 abstract "Correct hematopoietic differentiation requires the tightly regulated execution of lineage-specific and stage-restricted gene expression programs. This process is disturbed in hematological malignancies that typically show incomplete differentiation but often also display a mixed lineage phenotype. Co-expression of lymphoid and myeloid molecules is a well-known feature of acute myeloblastic leukemia (AML) with t(8;21). These cells consistently express the B-cell-specific transcription factor PAX5, and the B-cell-specific cell surface protein CD19. However, the functional consequences of PAX5 expression are unknown. To address this question, we studied the chromatin features of CD19, which is a direct target of PAX5 in cells with and without the t(8;21) chromosomal translocation. We show that CD19 chromatin exists in a poised configuration in myeloid progenitors and that this poised chromatin structure facilitates PAX5-dependent CD19 activation. Our results also show a positive correlation between PAX5 and CD19 expression in t(8;21)-positive AML cells and demonstrate that PAX5 binds to the promoter and enhancer of CD19 gene and remodels chromatin structure at the promoter. This study shows that expression of PAX5 in leukemic cells has functional consequences and points to an important role of a progenitor-specific chromatin configuration in myeloid leukemia." @default.
• W1994554141 created "2016-06-24" @default.
• W1994554141 creator A5012590429 @default.
• W1994554141 creator A5017439535 @default.
• W1994554141 creator A5023773042 @default.
• W1994554141 creator A5027017168 @default.
• W1994554141 creator A5030791454 @default.
• W1994554141 creator A5047593916 @default.
• W1994554141 creator A5056124968 @default.
• W1994554141 creator A5069764840 @default.
• W1994554141 creator A5088045469 @default.
• W1994554141 creator A5089878731 @default.
• W1994554141 date "2010-03-08" @default.
• W1994554141 modified "2023-10-17" @default.
• W1994554141 title "Aberrant expression of CD19 in AML with t(8;21) involves a poised chromatin structure and PAX5" @default.
• W1994554141 cites W1489323849 @default.
• W1994554141 cites W1617267715 @default.
• W1994554141 cites W1649547160 @default.
• W1994554141 cites W1963554993 @default.
• W1994554141 cites W1966969776 @default.
• W1994554141 cites W1973023394 @default.
• W1994554141 cites W1974604287 @default.
• W1994554141 cites W1977123213 @default.
• W1994554141 cites W1978688347 @default.
• W1994554141 cites W1981354816 @default.
• W1994554141 cites W1983409497 @default.
• W1994554141 cites W1991766825 @default.
• W1994554141 cites W2014263454 @default.
• W1994554141 cites W2016730049 @default.
• W1994554141 cites W2019291081 @default.
• W1994554141 cites W2022978842 @default.
• W1994554141 cites W2032582943 @default.
• W1994554141 cites W2034427054 @default.
• W1994554141 cites W2034648844 @default.
• W1994554141 cites W2044993404 @default.
• W1994554141 cites W2051886380 @default.
• W1994554141 cites W2061837158 @default.
• W1994554141 cites W2065839571 @default.
• W1994554141 cites W2069029811 @default.
• W1994554141 cites W2081870862 @default.
• W1994554141 cites W2085033687 @default.
• W1994554141 cites W2086738987 @default.
• W1994554141 cites W2086862639 @default.
• W1994554141 cites W2091655002 @default.
• W1994554141 cites W2093588238 @default.
• W1994554141 cites W2097519948 @default.
• W1994554141 cites W2105053762 @default.
• W1994554141 cites W2109810456 @default.
• W1994554141 cites W2117198005 @default.
• W1994554141 cites W2125310129 @default.
• W1994554141 cites W2126140071 @default.
• W1994554141 cites W2133581509 @default.
• W1994554141 cites W2141056582 @default.
• W1994554141 cites W2141635409 @default.
• W1994554141 cites W2143591283 @default.
• W1994554141 cites W2153464648 @default.
• W1994554141 cites W2155690291 @default.
• W1994554141 cites W2171900321 @default.
• W1994554141 cites W4234192722 @default.
• W1994554141 cites W4242768770 @default.
• W1994554141 cites W4244605157 @default.
• W1994554141 cites W990603645 @default.
• W1994554141 doi "https://doi.org/10.1038/onc.2010.56" @default.
• W1994554141 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20208555" @default.
• W1994554141 hasPublicationYear "2010" @default.
• W1994554141 type Work @default.
• W1994554141 sameAs 1994554141 @default.
• W1994554141 citedByCount "30" @default.
• W1994554141 countsByYear W19945541412012 @default.
• W1994554141 countsByYear W19945541412013 @default.
• W1994554141 countsByYear W19945541412014 @default.
• W1994554141 countsByYear W19945541412015 @default.
• W1994554141 countsByYear W19945541412016 @default.
• W1994554141 countsByYear W19945541412017 @default.
• W1994554141 countsByYear W19945541412018 @default.
• W1994554141 countsByYear W19945541412019 @default.
• W1994554141 countsByYear W19945541412020 @default.
• W1994554141 countsByYear W19945541412021 @default.
• W1994554141 countsByYear W19945541412022 @default.
• W1994554141 countsByYear W19945541412023 @default.
• W1994554141 crossrefType "journal-article" @default.
• W1994554141 hasAuthorship W1994554141A5012590429 @default.
• W1994554141 hasAuthorship W1994554141A5017439535 @default.
• W1994554141 hasAuthorship W1994554141A5023773042 @default.
• W1994554141 hasAuthorship W1994554141A5027017168 @default.
• W1994554141 hasAuthorship W1994554141A5030791454 @default.
• W1994554141 hasAuthorship W1994554141A5047593916 @default.
• W1994554141 hasAuthorship W1994554141A5056124968 @default.
• W1994554141 hasAuthorship W1994554141A5069764840 @default.
• W1994554141 hasAuthorship W1994554141A5088045469 @default.
• W1994554141 hasAuthorship W1994554141A5089878731 @default.
• W1994554141 hasBestOaLocation W19945541411 @default.
• W1994554141 hasConcept C104317684 @default.
• W1994554141 hasConcept C109159458 @default.
• W1994554141 hasConcept C148738053 @default.
• W1994554141 hasConcept C1491633281 @default.
• W1994554141 hasConcept C153911025 @default.
• W1994554141 hasConcept C159654299 @default.

• next