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- W1994557963 abstract "We have examined whether the development of embryonic muscle fiber type is regulated by competing influences between Hedgehog and TGF-β signals, as previously shown for development of neuronal cell identity in the neural tube. We found that ectopic expression of Hedgehogs or inhibition of protein kinase A in zebrafish embryos induces slow muscle precursors throughout the somite but muscle pioneer cells only in the middle of the somite. Ectopic expression in the notochord of Dorsalin-1, a member of the TGF-β superfamily, inhibits the formation of muscle pioneer cells, demonstrating that TGF-β signals can antagonize the induction of muscle pioneer cells by Hedgehog. We propose that a Hedgehog signal first induces the formation of slow muscle precursor cells, and subsequent Hedgehog and TGF-β signals exert competing positive and negative influences on the development of muscle pioneer cells." @default.
- W1994557963 created "2016-06-24" @default.
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- W1994557963 date "1997-10-06" @default.
- W1994557963 modified "2023-10-10" @default.
- W1994557963 title "Positive and Negative Regulation of Muscle Cell Identity by Members of the hedgehog and TGF-β Gene Families" @default.
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- W1994557963 doi "https://doi.org/10.1083/jcb.139.1.145" @default.
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