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- W1994558598 abstract "Polyomavirus (PyV) infection induces protective T-cell-independent (TI) IgM and IgG responses in T-cell-deficient (TCR βxδ−/−) mice. In this study, we show that PyV is a TI -2 antigen: B cells with a mutated Bruton's tyrosine kinase (Xid mutants) do not respond to PyV with antibody secretion in the absence of T cells. We also demonstrate that NK-cell-mediated “help” is not absolutely required for the induction of the TI-2 antibodies to PyV; thus for the first time, we provide evidence for protective IgM and IgG responses against a viral infection induced in mice lacking T and NK cells (CD3Etg). Comparison of the antibody responses observed in T- and NK-cell-deficient mice with those of mice lacking only T cells, however, suggests that NK cells may promote isotype switching to IgG2a. This effect is probably mediated by IFNγ secretion. In support of this idea, studies on the antibody responses of PyV-infected SCID mice that had been reconstituted with IFNγR−/− B cells or wild-type B cells demonstrated the IFNγ dependence of PyV-specific TI IgG2a secretion and provided evidence that IFNγ acting directly on B cells plays an important role in TI pathways of isotype switching to IgG2a in vivo." @default.
- W1994558598 created "2016-06-24" @default.
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- W1994558598 date "2001-02-01" @default.
- W1994558598 modified "2023-10-01" @default.
- W1994558598 title "Antiviral T-Cell-Independent Type 2 Antibody Responses Induced in Vivo in the Absence of T and NK Cells" @default.
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- W1994558598 doi "https://doi.org/10.1006/viro.2000.0766" @default.
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