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• W1994564394 startingPage "215" @default.
• W1994564394 abstract "Telomerase, an enzyme complex that binds the chromosome ends (telomeres) and maintains telomere length and integrity, is present in germ cells, proliferative granulosa cells, germline stem cells, and neoplastic cells in the ovary, but it is absent in differentiated or aged cells. Activation of telomerase in the ovary underpins both benign and malignant cell proliferation in several compartments, including the germ cells, membrana granulosa, and the ovarian surface epithelium. The difference in telomerase operation between normal and abnormal cell proliferations may lie in the mechanisms of telomerase activation in a deregulated manner. Recent studies have implicated telomerase activity in ovarian cancer as well as oogenesis and fertility. Inhibition of telomerase and the shortening of telomeres are seen in occult ovarian insufficiency. Studies of how telomerase operates and regulates ovary development may provide insight into the development of both germ cells for ovarian reproductive function and neoplastic cells in ovarian cancer. The current review summarizes the roles of telomerase in the development of oocytes and proliferation of granulosa cells during folliculogenesis and in the process of tumorigenesis. It also describes the regulation of telomerase by estrogen in the ovary." @default.
• W1994564394 created "2016-06-24" @default.
• W1994564394 creator A5000359400 @default.
• W1994564394 creator A5066286401 @default.
• W1994564394 date "2010-08-01" @default.
• W1994564394 modified "2023-09-24" @default.
• W1994564394 title "Telomerase in the ovary" @default.
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• W1994564394 doi "https://doi.org/10.1530/rep-10-0008" @default.
• W1994564394 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20562297" @default.
• W1994564394 hasPublicationYear "2010" @default.
• W1994564394 type Work @default.

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