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- W1994565093 abstract "Background Gene fusions are hybrid genes formed when two discrete genes are incorrectly joined together. Gene fusions are found to play roles in tumorigenesis. For example, the fusion gene BCR-ABL translates into an abnormal tyrosine kinase that accelerates development of chronic myelogenous leukemia [1]. A network is a relational representation of nodes (e.g., genes) with edges, and is a useful approach to explore biological interactions among many related nodes. Network analysis of gene fusions in cancer would aid the exploration of gene fusion occurrence and association with tumorigenesis. Hoglund et al [2] performed an initial investigation of gene fusions network after collecting 291 tumorigenesis related gene fusions from the Mitelman database in 2006. Since then, gene fusion data has exponentially increased. There is no current and comprehensive cancer-related gene fusion network to assist in targeting cancer-associated genes." @default.
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- W1994565093 date "2013-10-01" @default.
- W1994565093 modified "2023-10-09" @default.
- W1994565093 title "Network analysis of gene fusions in human cancer" @default.
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- W1994565093 doi "https://doi.org/10.1186/1471-2105-14-s17-a13" @default.
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