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• W1994566315 abstract "The protective effect of an alpha-toxoid vaccine of Clostridium septicum purified alpha-toxin was investigated in guinea pigs. Purified alpha-toxin was treated with formalin to make toxoid, and alpha-toxoid vaccine was prepared by mixing alpha-toxoid (4 to 64 μg/dose) with an aluminum phosphate gel as adjuvant. Guinea pigs were immunized twice with different doses of alpha-toxoid vaccine, and challenged with spores of C. septicum. The guinea pigs surviving after challenge had been immunized with 8 μg/dose or more of alpha-toxoid. All these animals produced titers of 20 units or higher of antitoxin at the challenge. The results suggest that C. septicum alpha-toxin plays an important role in protection against challenge with spores in guinea pigs." @default.
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• W1994566315 date "2002-01-01" @default.
• W1994566315 modified "2023-10-17" @default.
• W1994566315 title "Protective Effect of Clostridium septicum Alpha-Toxoid Vaccine against Challenge with Spores in Guinea Pigs." @default.
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• W1994566315 doi "https://doi.org/10.1292/jvms.64.67" @default.
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