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- W1994568248 abstract "Isatin (indole 2,3-dione) and its 5-chloro and 5-bromo derivatives have been reacted with 3-(4’-pyridyl)-4-amino-5-mercapto-4-(H)-1,2,4-triazole to form Schiff bases and the N-Mannich bases of these compounds were synthesised by reacting them with formaldehyde and several secondary amines. Their chemical structures have been confirmed by means of their IR, 1H-NMR data and by elemental analysis. Investigation of antimicrobial activity of compounds was done by agar dilution method against 27 pathogenic bacteria, 8 pathogenic fungi and anti-HIV activity against replication of HIV-1 (III B) in MT-4 cells. Among the compounds tested 1-(piperidinomethyl) 5-bromo 3-[3’-(4”-pyridyl)-5’-mercapto-4’-(H) 1’,2’,4’-triazol 4’-yl]imino isatin showed the most favourable antimicrobial activity." @default.
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- W1994568248 date "2010-06-09" @default.
- W1994568248 modified "2023-09-26" @default.
- W1994568248 title "ChemInform Abstract: Synthesis, Antibacterial, Antifungal and Anti-HIV Evaluation of Schiff and Mannich Bases of Isatin and Its Derivatives with Triazole." @default.
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- W1994568248 doi "https://doi.org/10.1002/chin.200015118" @default.
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