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• W1994575037 abstract "Thermodynamics impose a major constraint on the structure of metabolic pathways. Here, we use carbon fixation pathways to demonstrate how thermodynamics shape the structure of pathways and determine the cellular resources they consume. We analyze the energetic profile of prototypical reactions and show that each reaction type displays a characteristic change in Gibbs energy. Specifically, although carbon fixation pathways display a considerable structural variability, they are all energetically constrained by two types of reactions: carboxylation and carboxyl reduction. In fact, all adenosine triphosphate (ATP) molecules consumed by carbon fixation pathways - with a single exception - are used, directly or indirectly, to power one of these unfavorable reactions. When an indirect coupling is employed, the energy released by ATP hydrolysis is used to establish another chemical bond with high energy of hydrolysis, e.g. a thioester. This bond is cleaved by a downstream enzyme to energize an unfavorable reaction. Notably, many pathways exhibit reduced ATP requirement as they couple unfavorable carboxylation or carboxyl reduction reactions to exergonic reactions other than ATP hydrolysis. In the most extreme example, the reductive acetyl coenzyme A (acetyl-CoA) pathway bypasses almost all ATP-consuming reactions. On the other hand, the reductive pentose phosphate pathway appears to be the least ATP-efficient because it is the only carbon fixation pathway that invests ATP in metabolic aims other than carboxylation and carboxyl reduction. Altogether, our analysis indicates that basic thermodynamic considerations accurately predict the resource investment required to support a metabolic pathway and further identifies biochemical mechanisms that can decrease this requirement." @default.
• W1994575037 created "2016-06-24" @default.
• W1994575037 creator A5021074279 @default.
• W1994575037 creator A5024451873 @default.
• W1994575037 creator A5044028530 @default.
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• W1994575037 date "2012-09-01" @default.
• W1994575037 modified "2023-09-30" @default.
• W1994575037 title "Thermodynamic constraints shape the structure of carbon fixation pathways" @default.
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• W1994575037 doi "https://doi.org/10.1016/j.bbabio.2012.05.002" @default.
• W1994575037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22609686" @default.
• W1994575037 hasPublicationYear "2012" @default.
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