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- W1994580283 abstract "Thirteen aminoglycoside antibiotics were investigated with respect to their ability to replace Ca from phosphatidylserine monolayers. The affinities of the glycosides for the Ca-binding sites depended on the pH and the Ca2+ concentration of the aqueous subphase. At a Ca2+ concentration of 1.2 × 10−5 M and a pH of 7.5 the half maximum concentrations to replace Ca were found to range from 0.4 × 10−6 (sisomicin) to 6 × 10−6 M (streptomycin). The interaction between the streptomycins and Ca were of a competitive nature, whereas the aminoglycoside antibiotics with higher affinities displayed unusual steep dose-response curves suggesting positive cooperativity. The aminoglycoside antibiotics were also able to replace Ca from biomembranes (red cell ghosts and isolated sarcolemma of cardiac muscle) in a dose-dependent manner. The high affinity of aminoglycoside antibiotics to a phospholipid is considered to be involved in the toxic side effects of these antibiotics, e.g. nephrotoxicity and impairment of contractile force." @default.
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- W1994580283 date "1982-12-01" @default.
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- W1994580283 title "An interaction of aminoglycoside antibiotics with Ca binding to lipid monolayers and to biomembranes" @default.
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- W1994580283 doi "https://doi.org/10.1016/0006-2952(82)90291-x" @default.
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