FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994587515> ?p ?o ?g. }

• W1994587515 endingPage "148" @default.
• W1994587515 startingPage "137" @default.
• W1994587515 abstract "Using a model of established malignancy, we found that cyclophosphamide (Cy), administered at a dose not requiring hematopoietic stem cell support, is superior to low-dose total body irradiation in augmenting antitumor immunity. We observed that Cy administration resulted in expansion of tumor antigen-specific T cells and transient depletion of CD4+Foxp3+ regulatory T cells (Tregs). The antitumor efficacy of Cy was not improved by administration of anti-CD25 monoclonal antibody given to induce more profound Treg depletion. We found that Cy, through its myelosuppressive action, induced rebound myelopoiesis and perturbed dendritic cell (DC) homeostasis. The resulting DC turnover led to the emergence of tumor-infiltrating DCs that secreted more IL-12 and less IL-10 compared to those from untreated tumor-bearing animals. These newly recruited DCs, originating from proliferating early DC progenitors, were fully capable of priming T cell responses and ineffective in inducing expansion of Tregs. Together, our results show that Cy-mediated antitumor effects extend beyond the well-documented cytotoxicity and lymphodepletion and include resetting the DC homeostasis, thus providing an excellent platform for integration with other immunotherapeutic strategies." @default.
• W1994587515 created "2016-06-24" @default.
• W1994587515 creator A5004259150 @default.
• W1994587515 creator A5004862046 @default.
• W1994587515 creator A5044508050 @default.
• W1994587515 creator A5056345529 @default.
• W1994587515 creator A5071896200 @default.
• W1994587515 creator A5073444353 @default.
• W1994587515 creator A5075915892 @default.
• W1994587515 date "2009-07-10" @default.
• W1994587515 modified "2023-09-25" @default.
• W1994587515 title "Cyclophosphamide resets dendritic cell homeostasis and enhances antitumor immunity through effects that extend beyond regulatory T cell elimination" @default.
• W1994587515 cites W1491342045 @default.
• W1994587515 cites W1555526178 @default.
• W1994587515 cites W1565732077 @default.
• W1994587515 cites W1761128998 @default.
• W1994587515 cites W1932652245 @default.
• W1994587515 cites W1973592619 @default.
• W1994587515 cites W1976445933 @default.
• W1994587515 cites W1983923482 @default.
• W1994587515 cites W1986664303 @default.
• W1994587515 cites W1989574516 @default.
• W1994587515 cites W1999132647 @default.
• W1994587515 cites W2008858821 @default.
• W1994587515 cites W2016612145 @default.
• W1994587515 cites W2028105938 @default.
• W1994587515 cites W2037086694 @default.
• W1994587515 cites W2038381158 @default.
• W1994587515 cites W2038725731 @default.
• W1994587515 cites W2047203592 @default.
• W1994587515 cites W2048143404 @default.
• W1994587515 cites W2048793063 @default.
• W1994587515 cites W2060578098 @default.
• W1994587515 cites W2068971398 @default.
• W1994587515 cites W2069640685 @default.
• W1994587515 cites W2077829227 @default.
• W1994587515 cites W2083991703 @default.
• W1994587515 cites W2085991037 @default.
• W1994587515 cites W2090685407 @default.
• W1994587515 cites W2091916930 @default.
• W1994587515 cites W2096196002 @default.
• W1994587515 cites W2096625946 @default.
• W1994587515 cites W2105700807 @default.
• W1994587515 cites W2106274007 @default.
• W1994587515 cites W2106469410 @default.
• W1994587515 cites W2113657892 @default.
• W1994587515 cites W2118987611 @default.
• W1994587515 cites W2119088830 @default.
• W1994587515 cites W2124373740 @default.
• W1994587515 cites W2127734125 @default.
• W1994587515 cites W2136786880 @default.
• W1994587515 cites W2137049683 @default.
• W1994587515 cites W2138163780 @default.
• W1994587515 cites W2139153458 @default.
• W1994587515 cites W2142750845 @default.
• W1994587515 cites W2149118203 @default.
• W1994587515 cites W2153512326 @default.
• W1994587515 cites W2156592930 @default.
• W1994587515 cites W2162137343 @default.
• W1994587515 cites W2162675860 @default.
• W1994587515 cites W2165800851 @default.
• W1994587515 cites W2166891849 @default.
• W1994587515 cites W2252334125 @default.
• W1994587515 cites W331114241 @default.
• W1994587515 cites W4232558662 @default.
• W1994587515 cites W4234147211 @default.
• W1994587515 cites W4241405539 @default.
• W1994587515 cites W4385404294 @default.
• W1994587515 doi "https://doi.org/10.1007/s00262-009-0734-3" @default.
• W1994587515 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3103867" @default.
• W1994587515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19590872" @default.
• W1994587515 hasPublicationYear "2009" @default.
• W1994587515 type Work @default.
• W1994587515 sameAs 1994587515 @default.
• W1994587515 citedByCount "93" @default.
• W1994587515 countsByYear W19945875152012 @default.
• W1994587515 countsByYear W19945875152013 @default.
• W1994587515 countsByYear W19945875152014 @default.
• W1994587515 countsByYear W19945875152015 @default.
• W1994587515 countsByYear W19945875152016 @default.
• W1994587515 countsByYear W19945875152017 @default.
• W1994587515 countsByYear W19945875152018 @default.
• W1994587515 countsByYear W19945875152019 @default.
• W1994587515 countsByYear W19945875152020 @default.
• W1994587515 countsByYear W19945875152021 @default.
• W1994587515 countsByYear W19945875152022 @default.
• W1994587515 crossrefType "journal-article" @default.
• W1994587515 hasAuthorship W1994587515A5004259150 @default.
• W1994587515 hasAuthorship W1994587515A5004862046 @default.
• W1994587515 hasAuthorship W1994587515A5044508050 @default.
• W1994587515 hasAuthorship W1994587515A5056345529 @default.
• W1994587515 hasAuthorship W1994587515A5071896200 @default.
• W1994587515 hasAuthorship W1994587515A5073444353 @default.
• W1994587515 hasAuthorship W1994587515A5075915892 @default.
• W1994587515 hasBestOaLocation W19945875152 @default.
• W1994587515 hasConcept C100701293 @default.
• W1994587515 hasConcept C109159458 @default.
• W1994587515 hasConcept C203014093 @default.

• next