FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994590448> ?p ?o ?g. }

• W1994590448 endingPage "757" @default.
• W1994590448 startingPage "745" @default.
• W1994590448 abstract "Craniofacial and neural tissues develop in concert throughout prenatal and postnatal growth. FGFR-related craniosynostosis syndromes, such as Apert syndrome (AS), are associated with specific phenotypes involving both the skull and the brain. We analyzed the effects of the FGFR P253R mutation for AS using the Fgfr2(+/P253R) Apert syndrome mouse to evaluate the effects of this mutation on these two tissues over the course of development from day of birth (P0) to postnatal day 2 (P2). Three-dimensional magnetic resonance microscopy and computed tomography images were acquired from Fgfr2(+/P253R) mice and unaffected littermates at P0 (N = 28) and P2 (N = 20).Three-dimensional coordinate data for 23 skull and 15 brain landmarks were statistically compared between groups. Results demonstrate that the Fgfr2(+/P253R) mice show reduced growth in the facial skeleton and the cerebrum, while the height and width of the neurocranium and caudal regions of the brain show increased growth relative to unaffected littermates. This localized correspondence of differential growth patterns in skull and brain point to their continued interaction through development and suggest that both tissues display divergent postnatal growth patterns relative to unaffected littermates. However, the change in the skull-brain relationship from P0 to P2 implies that each tissue affected by the mutation retains a degree of independence, rather than one tissue directing the development of the other." @default.
• W1994590448 created "2016-06-24" @default.
• W1994590448 creator A5003395715 @default.
• W1994590448 creator A5008176767 @default.
• W1994590448 creator A5015648857 @default.
• W1994590448 creator A5030740506 @default.
• W1994590448 creator A5035104305 @default.
• W1994590448 creator A5051345459 @default.
• W1994590448 creator A5069000177 @default.
• W1994590448 creator A5076084077 @default.
• W1994590448 date "2013-03-12" @default.
• W1994590448 modified "2023-09-25" @default.
• W1994590448 title "Postnatal brain and skull growth in an Apert syndrome mouse model" @default.
• W1994590448 cites W1445133092 @default.
• W1994590448 cites W1481277852 @default.
• W1994590448 cites W1503329970 @default.
• W1994590448 cites W1546479867 @default.
• W1994590448 cites W1579351129 @default.
• W1994590448 cites W1835943580 @default.
• W1994590448 cites W1964605565 @default.
• W1994590448 cites W1976771795 @default.
• W1994590448 cites W1977144442 @default.
• W1994590448 cites W1981804979 @default.
• W1994590448 cites W1990297564 @default.
• W1994590448 cites W1991484564 @default.
• W1994590448 cites W1996209316 @default.
• W1994590448 cites W1997751772 @default.
• W1994590448 cites W1998159493 @default.
• W1994590448 cites W2001896944 @default.
• W1994590448 cites W2003919174 @default.
• W1994590448 cites W2006019715 @default.
• W1994590448 cites W2009425793 @default.
• W1994590448 cites W2010843037 @default.
• W1994590448 cites W2012498641 @default.
• W1994590448 cites W2017956584 @default.
• W1994590448 cites W2027319896 @default.
• W1994590448 cites W2027770279 @default.
• W1994590448 cites W2036534012 @default.
• W1994590448 cites W2045366578 @default.
• W1994590448 cites W2047410473 @default.
• W1994590448 cites W2048506770 @default.
• W1994590448 cites W2050468398 @default.
• W1994590448 cites W2067732333 @default.
• W1994590448 cites W2068208801 @default.
• W1994590448 cites W2069499424 @default.
• W1994590448 cites W2072490815 @default.
• W1994590448 cites W2074747649 @default.
• W1994590448 cites W2074788948 @default.
• W1994590448 cites W2075957952 @default.
• W1994590448 cites W2076274660 @default.
• W1994590448 cites W2089558318 @default.
• W1994590448 cites W2102601997 @default.
• W1994590448 cites W2110011900 @default.
• W1994590448 cites W2111096971 @default.
• W1994590448 cites W2113771280 @default.
• W1994590448 cites W2117757706 @default.
• W1994590448 cites W2124937454 @default.
• W1994590448 cites W2128550660 @default.
• W1994590448 cites W2133225387 @default.
• W1994590448 cites W2135785897 @default.
• W1994590448 cites W2143858459 @default.
• W1994590448 cites W2146967433 @default.
• W1994590448 cites W2147294429 @default.
• W1994590448 cites W2159836347 @default.
• W1994590448 cites W2224335487 @default.
• W1994590448 cites W2336309438 @default.
• W1994590448 cites W2417013347 @default.
• W1994590448 cites W283106291 @default.
• W1994590448 cites W4230516909 @default.
• W1994590448 cites W4238804122 @default.
• W1994590448 cites W4296421316 @default.
• W1994590448 doi "https://doi.org/10.1002/ajmg.a.35805" @default.
• W1994590448 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3606655" @default.
• W1994590448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23495236" @default.
• W1994590448 hasPublicationYear "2013" @default.
• W1994590448 type Work @default.
• W1994590448 sameAs 1994590448 @default.
• W1994590448 citedByCount "27" @default.
• W1994590448 countsByYear W19945904482014 @default.
• W1994590448 countsByYear W19945904482015 @default.
• W1994590448 countsByYear W19945904482016 @default.
• W1994590448 countsByYear W19945904482017 @default.
• W1994590448 countsByYear W19945904482018 @default.
• W1994590448 countsByYear W19945904482019 @default.
• W1994590448 countsByYear W19945904482020 @default.
• W1994590448 countsByYear W19945904482022 @default.
• W1994590448 countsByYear W19945904482023 @default.
• W1994590448 crossrefType "journal-article" @default.
• W1994590448 hasAuthorship W1994590448A5003395715 @default.
• W1994590448 hasAuthorship W1994590448A5008176767 @default.
• W1994590448 hasAuthorship W1994590448A5015648857 @default.
• W1994590448 hasAuthorship W1994590448A5030740506 @default.
• W1994590448 hasAuthorship W1994590448A5035104305 @default.
• W1994590448 hasAuthorship W1994590448A5051345459 @default.
• W1994590448 hasAuthorship W1994590448A5069000177 @default.
• W1994590448 hasAuthorship W1994590448A5076084077 @default.
• W1994590448 hasBestOaLocation W19945904482 @default.
• W1994590448 hasConcept C105702510 @default.

• next