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• W1994604574 abstract "To investigate cellular death in the neurosensory portion of the retina during the first 7 days after onset of clinical signs of overt primary angleclosure glaucoma (PACG) in dogs.14 globes from dogs with PACG and 2 normotensive globes from dogs with PACG in the opposite eye.Retinas were examined via light microscopy and terminal deoxynucleotidyl transferase-mediated biotin-dUTP nick end-labeling.Necrosis of ganglion cells and segmental degeneration of the nerve fiber layer rapidly progressed to scattered full-thickness retinal attenuation and disorganization. Apoptosis was detectable within 1 day after onset of PACG and was prominent by 3 days. Necrosis of ganglion cells was significantly greater in retinas affected for < or = 1 day, compared with retinas affected for > 1 day. In contrast, apoptosis in the ganglion cell layer was significantly greater in retinas affected for > 1 day, compared with retinas affected for < or = 1 day. End-stage retinal atrophy was seen by day 7.The presence of necrotic ganglion cells within 1 day after onset of clinical signs suggests a narrow window of opportunity to initiate effective therapy in overt PACG. Photoreceptor death is an important and striking aspect of neurosensory retinal degeneration after acute onset of PACG." @default.
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• W1994604574 date "2002-02-01" @default.
• W1994604574 modified "2023-09-27" @default.
• W1994604574 title "Morphologic features of degeneration and cell death in the neurosensory retina in dogs with primary angle-closure glaucoma" @default.
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• W1994604574 doi "https://doi.org/10.2460/ajvr.2002.63.257" @default.
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