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• W1994612911 abstract "Depression is characterized by inflammation and cell-mediated immune (CMI) activation and autoimmune reactions directed against a multitude of self-epitopes. There is evidence that the inflammatory response in depression causes dysfunctions in the metabolism of 5-HT, e.g. lowering the 5-HT precursor tryptophan, and upregulating 5-HT receptor mRNA. This study has been undertaken to examine autoimmune activity directed against 5-HT in relation to CMI activation and inflammation.5-HT antibodies were examined in major depressed patients (n=109) versus normal controls (n=35) in relation to serum neopterin and lysozyme, and plasma pro-inflammatory cytokines (PIC), i.e. interleukin-1 (IL-1) and tumor necrosis factor-α (TNFα). Severity of depression was assessed with the Hamilton Depression Rating Scale (HDRS) and severity of fatigue and somatic symptoms with the Fibromyalgia and Chronic Fatigue Syndrome (FF) Rating Scale.The incidence of anti-5-HT antibody activity was significantly higher in depressed patients (54.1%), and in particular in those with melancholia (82.9%), than in controls (5.7%). Patients with positive 5-HT antibodies showed increased serum neopterin and lysozyme, and plasma TNFα and IL-1; higher scores on the HDRS and FF scales, and more somatic symptoms, including malaise and neurocognitive dysfunctions. There was a significant association between autoimmune activity to 5-HT and the number of previous depressive episodes.The autoimmune reactions directed against 5-HT might play a role in the pathophysiology of depression and the onset of severe depression. The strong association between autoimmune activity against 5-HT and inflammation/CMI activation is explained by multiple, reciprocal pathways between these factors. Exposure to previous depressive episodes increases the incidence of autoimmune activity directed against 5-HT, which in turn may increase the likelihood to develop new depressive episodes. These findings suggest that sensitization (kindling) and staging of depression are in part based on progressive autoimmune responses." @default.
• W1994612911 created "2016-06-24" @default.
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• W1994612911 date "2012-02-01" @default.
• W1994612911 modified "2023-10-16" @default.
• W1994612911 title "Increased autoimmune activity against 5-HT: A key component of depression that is associated with inflammation and activation of cell-mediated immunity, and with severity and staging of depression" @default.
• W1994612911 cites W1548692828 @default.
• W1994612911 cites W1967879639 @default.
• W1994612911 cites W1970718685 @default.
• W1994612911 cites W1978552550 @default.
• W1994612911 cites W1978702665 @default.
• W1994612911 cites W1979873771 @default.
• W1994612911 cites W1980259022 @default.
• W1994612911 cites W1981163610 @default.
• W1994612911 cites W1986275520 @default.
• W1994612911 cites W1989764712 @default.
• W1994612911 cites W1997361683 @default.
• W1994612911 cites W1999609139 @default.
• W1994612911 cites W2002040411 @default.
• W1994612911 cites W2003189568 @default.
• W1994612911 cites W2007043862 @default.
• W1994612911 cites W2008779800 @default.
• W1994612911 cites W2011553061 @default.
• W1994612911 cites W2011912466 @default.
• W1994612911 cites W2013550027 @default.
• W1994612911 cites W2018049815 @default.
• W1994612911 cites W2020533233 @default.
• W1994612911 cites W2022241882 @default.
• W1994612911 cites W2023191544 @default.
• W1994612911 cites W2029755823 @default.
• W1994612911 cites W2031480010 @default.
• W1994612911 cites W2034648083 @default.
• W1994612911 cites W2039268423 @default.
• W1994612911 cites W2044390612 @default.
• W1994612911 cites W2059323818 @default.
• W1994612911 cites W2060345189 @default.
• W1994612911 cites W2063084227 @default.
• W1994612911 cites W2063636743 @default.
• W1994612911 cites W2064965507 @default.
• W1994612911 cites W2065313926 @default.
• W1994612911 cites W2069908976 @default.
• W1994612911 cites W2074349137 @default.
• W1994612911 cites W2074877998 @default.
• W1994612911 cites W2075425257 @default.
• W1994612911 cites W2076244671 @default.
• W1994612911 cites W2076423355 @default.
• W1994612911 cites W2076450386 @default.
• W1994612911 cites W2079679375 @default.
• W1994612911 cites W2079819775 @default.
• W1994612911 cites W2084868697 @default.
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• W1994612911 doi "https://doi.org/10.1016/j.jad.2011.11.016" @default.
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