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- W1994620171 endingPage "304" @default.
- W1994620171 startingPage "292" @default.
- W1994620171 abstract "In situ forming implants (ISI) based on phase separation by solvent exchange represent an attractive alternative to conventional preformed implants and microparticles for parenteral applications. They are indeed easier to manufacture and their administration does not require surgery, therefore improving patient compliance. They consist of polymeric solutions precipitating at the site of injection and thus forming a drug eluting depot. Drug release from ISI is typically divided into three phases: burst during precipitation of the depot, diffusion of drug through the polymeric matrix and finally drug release by system degradation. This review gives a comprehensive overview on (i) the theoretical bases of these three phases, (ii) the parameters influencing them and (iii) the remaining drawbacks which have to be addressed to enlarge their commercial opportunities. Indeed, although some of them are already commercialized, ISI still suffer from limitations: mainly lack of reproducibility in depot shape, burst during solidification and potential toxicity. Nevertheless, depending on the targeted therapeutic application, these shortcomings may be transformed into advantages. As a result, keys are given in order to tailor these formulations in view of the desired application so that ISI could gain further clinical importance in the following years." @default.
- W1994620171 created "2016-06-24" @default.
- W1994620171 creator A5003109398 @default.
- W1994620171 creator A5062281685 @default.
- W1994620171 creator A5065197771 @default.
- W1994620171 creator A5069768407 @default.
- W1994620171 creator A5072953717 @default.
- W1994620171 creator A5079147265 @default.
- W1994620171 date "2013-11-01" @default.
- W1994620171 modified "2023-10-11" @default.
- W1994620171 title "PLGA in situ implants formed by phase inversion: Critical physicochemical parameters to modulate drug release" @default.
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