FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994632714> ?p ?o ?g. }

• W1994632714 endingPage "326" @default.
• W1994632714 startingPage "319" @default.
• W1994632714 abstract "As part of the innate and adaptive immune system, airway epithelial cells secrete proinflammatory cytokines after activation of Toll-like receptors (TLRs) by pathogens. Nevertheless, cystic fibrosis (CF) airways are chronically infected with Pseudomonas aeruginosa, suggesting a modified immune response in CF. The authors have shown that in CF bronchial epithelial cells, a reduced surface expression of TLR-4 causes a diminished interleukin (IL)-8 and IL-6 response upon lipopolysaccharide (LPS) stimulation. However, there is no information regarding activation of the MyD88 (myeloid differentiation primary response gene 88)-independent TLR-4 signaling pathway by LPS, which results in the activation of adaptive immune responses by secretion of the T cell–recruiting chemokine interferon-γ–inducible protein (IP)-10. Therefore, the authors investigated the induction of IP-10 in CF bronchial epithelial cell line CFBE41o− and its CFTR-corrected isotype under well-differentiating conditions. TLR-4 surface expression was significantly reduced in CFBE41o− by a factor of 2, compared to the CFTR-corrected cells. In CFTR-corrected cells, stimulation with LPS increased IP-10 secretion. Incubating cells with siRNA directed against TLR-4 inhibited the LPS stimulated increase of IP-10 in CFTR-corrected cells. The reduced TLR-4 surface expression in CF cells causes the loss of induction of IP-10 by LPS. This could compromise adaptive immune responses in CF due to a reduced T-cell recruitment." @default.
• W1994632714 created "2016-06-24" @default.
• W1994632714 creator A5042096190 @default.
• W1994632714 creator A5046074910 @default.
• W1994632714 creator A5050025826 @default.
• W1994632714 creator A5059572789 @default.
• W1994632714 creator A5089182357 @default.
• W1994632714 date "2011-06-07" @default.
• W1994632714 modified "2023-09-27" @default.
• W1994632714 title "Reduced surface toll-like receptor-4 expression and absent interferon-γ–inducible protein-10 induction in cystic fibrosis airway cells" @default.
• W1994632714 cites W1515441120 @default.
• W1994632714 cites W1557965441 @default.
• W1994632714 cites W1558470115 @default.
• W1994632714 cites W1967279039 @default.
• W1994632714 cites W1976904764 @default.
• W1994632714 cites W1982366378 @default.
• W1994632714 cites W1993993814 @default.
• W1994632714 cites W1998195903 @default.
• W1994632714 cites W1999746307 @default.
• W1994632714 cites W2000229886 @default.
• W1994632714 cites W2001980146 @default.
• W1994632714 cites W2028450839 @default.
• W1994632714 cites W2030074619 @default.
• W1994632714 cites W2038267036 @default.
• W1994632714 cites W2046216563 @default.
• W1994632714 cites W2048053168 @default.
• W1994632714 cites W2053522380 @default.
• W1994632714 cites W2057061730 @default.
• W1994632714 cites W2057846579 @default.
• W1994632714 cites W2058107166 @default.
• W1994632714 cites W2063498404 @default.
• W1994632714 cites W2075390708 @default.
• W1994632714 cites W2080056304 @default.
• W1994632714 cites W2082890018 @default.
• W1994632714 cites W2092733738 @default.
• W1994632714 cites W2095408626 @default.
• W1994632714 cites W2104629765 @default.
• W1994632714 cites W2120222530 @default.
• W1994632714 cites W2121167917 @default.
• W1994632714 cites W2130421043 @default.
• W1994632714 cites W2130509294 @default.
• W1994632714 cites W2134262275 @default.
• W1994632714 cites W2134912543 @default.
• W1994632714 cites W2137563519 @default.
• W1994632714 cites W2147064547 @default.
• W1994632714 cites W2147839947 @default.
• W1994632714 cites W2164331874 @default.
• W1994632714 cites W2166779461 @default.
• W1994632714 cites W2196784529 @default.
• W1994632714 doi "https://doi.org/10.3109/01902148.2011.569968" @default.
• W1994632714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21649525" @default.
• W1994632714 hasPublicationYear "2011" @default.
• W1994632714 type Work @default.
• W1994632714 sameAs 1994632714 @default.
• W1994632714 citedByCount "18" @default.
• W1994632714 countsByYear W19946327142012 @default.
• W1994632714 countsByYear W19946327142013 @default.
• W1994632714 countsByYear W19946327142014 @default.
• W1994632714 countsByYear W19946327142015 @default.
• W1994632714 countsByYear W19946327142016 @default.
• W1994632714 countsByYear W19946327142017 @default.
• W1994632714 countsByYear W19946327142020 @default.
• W1994632714 crossrefType "journal-article" @default.
• W1994632714 hasAuthorship W1994632714A5042096190 @default.
• W1994632714 hasAuthorship W1994632714A5046074910 @default.
• W1994632714 hasAuthorship W1994632714A5050025826 @default.
• W1994632714 hasAuthorship W1994632714A5059572789 @default.
• W1994632714 hasAuthorship W1994632714A5089182357 @default.
• W1994632714 hasConcept C13373296 @default.
• W1994632714 hasConcept C134018914 @default.
• W1994632714 hasConcept C136449434 @default.
• W1994632714 hasConcept C164027704 @default.
• W1994632714 hasConcept C193419808 @default.
• W1994632714 hasConcept C203014093 @default.
• W1994632714 hasConcept C2776709828 @default.
• W1994632714 hasConcept C2776914184 @default.
• W1994632714 hasConcept C2776938444 @default.
• W1994632714 hasConcept C2778690821 @default.
• W1994632714 hasConcept C2778754761 @default.
• W1994632714 hasConcept C49039625 @default.
• W1994632714 hasConcept C54355233 @default.
• W1994632714 hasConcept C86803240 @default.
• W1994632714 hasConcept C8891405 @default.
• W1994632714 hasConcept C95444343 @default.
• W1994632714 hasConceptScore W1994632714C13373296 @default.
• W1994632714 hasConceptScore W1994632714C134018914 @default.
• W1994632714 hasConceptScore W1994632714C136449434 @default.
• W1994632714 hasConceptScore W1994632714C164027704 @default.
• W1994632714 hasConceptScore W1994632714C193419808 @default.
• W1994632714 hasConceptScore W1994632714C203014093 @default.
• W1994632714 hasConceptScore W1994632714C2776709828 @default.
• W1994632714 hasConceptScore W1994632714C2776914184 @default.
• W1994632714 hasConceptScore W1994632714C2776938444 @default.
• W1994632714 hasConceptScore W1994632714C2778690821 @default.
• W1994632714 hasConceptScore W1994632714C2778754761 @default.
• W1994632714 hasConceptScore W1994632714C49039625 @default.
• W1994632714 hasConceptScore W1994632714C54355233 @default.
• W1994632714 hasConceptScore W1994632714C86803240 @default.

• next